ARHGAP12 and IL2RA

		ARHGAP12	IL2RA
Description		Rho GTPase activating protein 12	interleukin 2 receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Plasma Membrane Postsynapse Glutamatergic Synapse	Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Phagocytosis, Engulfment Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly	Immune System Process Inflammatory Response To Antigenic Stimulus Regulation Of T Cell Tolerance Induction Regulation Of Immune System Process Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Lymphocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		RAC1 GTPase cycle RHOD GTPase cycle RHOV GTPase cycle RHOF GTPase cycle	RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Basiliximab Daclizumab Inolimomab Camidanlumab tesirine
Diseases			Type I diabetes mellitus T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		C-reactive protein levels ( 24763700) Glycine levels ( 30837465) Intraocular pressure ( 31959993) Pulse pressure ( 27841878 28135244) Systolic blood pressure ( 27841878) Uterine fibroids ( 31649266)	Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Alopecia areata ( 20596022 25608926) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634 31959851 31619474 31361310 30929738 32296059) Asthma (adult onset) ( 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 30929738) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diisocyanate-induced asthma ( 25918132) Eczema ( 31361310) Emotional dysregulation ( 27643478) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Graves' disease ( 22922229) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Interleukin-2 receptor antagonist levels ( 27989323) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 19525953 17660530 19525955 21833088 28445677 24076602 22190364 27386562) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Plasma t-tau levels ( 28100725) Primary sclerosing cholangitis ( 27992413 23603763) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 30572963 30423114 24449572 24390342 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 30572963 25751624 22293688 21829393 19430480 18978792) Vitiligo ( 27723757 20410501) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: RAC1 SHANK2 SRPK1 SRPK2 TRIP10	8 interacting genes: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B
Entrez ID		94134	3559
HPRD ID		06446	00986
Ensembl ID		ENSG00000165322	ENSG00000134460
Uniprot IDs		Q1RLN5 Q8IWW6	H0Y5Z0 P01589 Q5W005
PDB IDs			1Z92 2B5I 2ERJ 3IU3 3NFP 6VWU 6YIO 7F9W 7ZMZ
Enriched GO Terms of Interacting Partners?		Phagocytic Cup Positive Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Interleukin-2 Receptor Complex Defense Response Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Viral Genome Replication Regulation Of Viral Life Cycle Negative Regulation Of Viral Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of T Cell Homeostatic Proliferation Interleukin-2 Binding Interleukin-2 Receptor Activity Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Regulation Of MRNA Processing Regulation Of Viral Process Nuclear Speck Organization Synaptic Receptor Adaptor Activity Homeostasis Of Number Of Cells Regulation Of Ovarian Follicle Development Cell Cortex Erythrocyte Enucleation Regulation Of RNA Splicing Regulation Of Synaptic Plasticity Auditory Receptor Cell Morphogenesis Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Protein-RNA Complex Assembly Magnesium Ion Binding Positive Regulation Of Cell Population Proliferation Activation-induced Cell Death Of T Cells Kinocilium G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Postsynaptic Membrane Hepatocyte Growth Factor Receptor Signaling Pathway Activated T Cell Proliferation Regulation Of Neuron Maturation Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering R-loop Processing Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production	Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Binding Cytokine-mediated Signaling Pathway Response To Peptide Response To Cytokine Positive Regulation Of Inflammatory Response Cellular Response To Interleukin-17 Activated T Cell Proliferation Cellular Response To Cytokine Stimulus Regulation Of Vitamin Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Immune Response Progesterone Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Alcohol Regulation Of Monoatomic Cation Transmembrane Transport Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cell Population Proliferation Response To Estradiol Positive Regulation Of T Cell Proliferation Adaptive Immune Response Positive Regulation Of Myeloid Cell Differentiation T Cell Activation Positive Regulation Of B Cell Differentiation Transcription By RNA Polymerase II Negative Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Response To Ethanol Growth Hormone Receptor Signaling Pathway C21-steroid Hormone Metabolic Process Regulation Of Metal Ion Transport Sex Differentiation Positive Regulation Of Activated T Cell Proliferation Cellular Response To Hormone Stimulus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation Regulation Of Transport Sodium Channel Regulator Activity Immune Effector Process Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Interleukin-2 Production Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Inflammatory Response
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