ORMDL3 and CCR7

		ORMDL3	CCR7
Description		ORMDL sphingolipid biosynthesis regulator 3	C-C motif chemokine receptor 7
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Serine Palmitoyltransferase Complex Secretory Granule Membrane Specific Granule Membrane	Mitochondrion Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity Chemokine (C-C Motif) Ligand 19 Binding Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 19 Receptor Activity C-C Motif Chemokine 21 Receptor Activity
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Regulation Of Smooth Muscle Contraction Positive Regulation Of Autophagy Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Regulation Of Ceramide Biosynthetic Process	Establishment Of T Cell Polarity Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Hypersensitivity Positive Regulation Of Humoral Immune Response Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Ruffle Organization Regulation Of Cdc42 Protein Signal Transduction Response To Lipopolysaccharide Regulation Of Type II Interferon Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Rac Protein Signal Transduction CCL19-activated CCR7 Signaling Pathway CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Thymic T Cell Selection Positive Regulation Of Cell Adhesion Positive Regulation Of JNK Cascade Positive Regulation Of Receptor-mediated Endocytosis Homeostasis Of Number Of Cells Positive Regulation Of T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Cellular Response To Prostaglandin E Stimulus Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Lymphocyte Migration Into Lymph Node Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Immunological Synapse Formation Positive Regulation Of T Cell Costimulation Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Asthma ( 17611496 29273806 31959851 28461288 22561531 21150878 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Autoimmune traits (pleiotropy) ( 30572963) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 21102463 28067908 18587394) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 25751624 30659077 21829393 19430480) Ulcerative colitis ( 28067908 21297633 20228799) White blood cell count ( 27863252 21738480)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 30929738 31959851) Asthma (childhood onset) ( 30929738) Eczema ( 31361310) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Takayasu arteritis ( 33308445) Triglyceride levels in HIV infection ( 33109212) Type 1 diabetes ( 25751624)
Interacting Genes		30 interacting genes: APP AQP6 ARL13B C10orf67 CERS3 COQ8A EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 LEPROTL1 LMNA LNX1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35H1 SLC7A1 SYT2 TMEM237	3 interacting genes: CCL19 CCL21 CCR10
Entrez ID		94103	1236
HPRD ID		17803	02588
Ensembl ID		ENSG00000172057	ENSG00000126353
Uniprot IDs		Q8N138	A0N0Q0 J3KSS9 P32248
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2	6QZH
Enriched GO Terms of Interacting Partners?		Membrane	Regulation Of Dendritic Cell Dendrite Assembly CCR7 Chemokine Receptor Binding Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Chemokine-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Establishment Of T Cell Polarity Negative Regulation Of Dendritic Cell Apoptotic Process Chemokine Receptor Binding Immunological Synapse Formation Dendritic Cell Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Eosinophil Chemotaxis Positive Regulation Of Glycoprotein Metabolic Process Eosinophil Migration Cell Chemotaxis Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Cellular Response To Prostaglandin Stimulus Positive Regulation Of Granulocyte Chemotaxis Response To Prostaglandin E CCR Chemokine Receptor Binding Negative Regulation Of Apoptotic Process Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Negative Regulation Of Programmed Cell Death Regulation Of Glycoprotein Biosynthetic Process Regulation Of Neutrophil Migration Chemotaxis T Cell Costimulation Chemokine Activity Locomotion Regulation Of Granulocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Recognition Negative Regulation Of Sequestering Of Calcium Ion Cytokine-mediated Signaling Pathway Granulocyte Chemotaxis Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium Ion Transmembrane Import Into Cytosol Establishment Of Cell Polarity Granulocyte Migration Positive Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Leukocyte Chemotaxis
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