MSLN and MUC16

Number of citations of the paper that reports this interaction (PMID 14676194)
84

Data Source:
HPRD (in vitro)

		MSLN	MUC16
Gene Name		mesothelin	mucin 16, cell surface associated
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane	Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Membrane Extrinsic Component Of Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Adhesion Pancreas Development	Protein O-linked Glycosylation Cell Adhesion O-glycan Processing Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification Termination of O-glycan biosynthesis O-linked glycosylation of mucins O-linked glycosylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MUC16 RSG1	3 interactors: LGALS1 MSLN UBC
Entrez ID		10232	94025
HPRD ID		03030	07548
Ensembl ID		ENSG00000102854	ENSG00000181143
Uniprot IDs		Q13421	B3KY81 B5ME49 Q8WXI7
PDB IDs		4F3F
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Erythrocyte Aggregation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Plasma Cell Differentiation Viral Protein Processing Mature B Cell Differentiation Involved In Immune Response Mature B Cell Differentiation Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Apoptotic Process Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Myoblast Differentiation Cell Death Death Negative Regulation Of ERBB Signaling Pathway B Cell Activation Involved In Immune Response Negative Regulation Of Cell-substrate Adhesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Glucose Stimulus Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		aml arrays bfm blinded ccl23 cytological cytology day15 day28 dismal gaged2 lab monitoring mrd multicenter normalized prame prognostic prospectively relapse rfs se spag6 st18 standardized stratified survived taqman wt1	altering arhi atlas belong brca1 ca125 clarified cnvs consequences copy diras3 dysregulated emphasis he4 imprinted messenger micrornas mirna mirnas mirs ovarian profiling projects remarkable rnas summarizes tcga variations wfdc2
Tagcloud (Difference) ?		aml arrays bfm blinded ccl23 cytological cytology day15 day28 dismal gaged2 lab monitoring mrd multicenter normalized prame prognostic prospectively relapse rfs se spag6 st18 standardized stratified survived taqman wt1	altering arhi atlas belong brca1 ca125 clarified cnvs consequences copy diras3 dysregulated emphasis he4 imprinted messenger micrornas mirna mirnas mirs ovarian profiling projects remarkable rnas summarizes tcga variations wfdc2
Tagcloud (Intersection) ?