MSLN and MUC16

Number of citations of the paper that reports this interaction (PubMedID 14676194)
0

Data Source:
HPRD (in vitro)

		MSLN	MUC16
Description		mesothelin	mucin 16, cell surface associated
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Cell Surface Membrane Side Of Membrane	Extracellular Region Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Membrane Vesicle Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion	Cell Adhesion
Pathways		Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs		Amatuximab	Dimethyl sulfoxide Oregovomab
Diseases
GWAS		Body mass index ( 26426971) Serum cancer antigen 125 (CA 125) levels ( 31666285)	Asthma ( 30929738 32296059) Hepcidin/transferrin saturation ratio ( 27846281) Serum cancer antigen 125 (CA 125) levels ( 31666285) Tourette syndrome ( 30818990)
Interacting Genes		3 interacting genes: APPBP2 CPLANE2 MUC16	3 interacting genes: LGALS1 MSLN UBC
Entrez ID		10232	94025
HPRD ID		03030	07548
Ensembl ID		ENSG00000102854	ENSG00000181143
Uniprot IDs		Q13421	A0AAG2UXK0 B3KY81 Q8WXI7
PDB IDs		4F3F 7U8C 7U9J 7UED 8CX3 8CXC 8CYH 8CZ8 8FSL 8VM1	7SA9 8GKL 8VM1 8VRS
Enriched GO Terms of Interacting Partners?			Lactose Binding Positive Regulation Of Dendritic Cell Differentiation Galectin Complex Negative Regulation Of T-helper 17 Cell Lineage Commitment Plasma Cell Differentiation Nuclear Migration Along Microfilament Microtubule-based Transport Nuclear Migration Along Microtubule Nuclear Matrix Organization Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Cytoskeleton-nuclear Membrane Anchor Activity Nuclear Matrix Anchoring At Nuclear Membrane Determination Of Heart Left/right Asymmetry Outer Dynein Arm Docking Complex
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