KCNG4 and KCNE5

Number of citations of the paper that reports this interaction (PubMedID 26242757)
36

Data Source:
BioGRID (fluorescent resonance energy transfer)

		KCNG4	KCNE5
Description		potassium voltage-gated channel modifier subfamily G member 4	potassium voltage-gated channel subfamily E regulatory subunit 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Potassium Channel Regulator Activity Transmembrane Transporter Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport	Monoatomic Ion Transport Regulation Of Heart Contraction Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Pathways		Voltage gated Potassium channels	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Enflurane Promethazine Miconazole	Enflurane Promethazine Miconazole
Diseases
GWAS		Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Systolic blood pressure (baseline) ( 33603002) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		3 interacting genes: KCNB1 KCNE5 KCNF1	7 interacting genes: APP GET3 KCNB1 KCNG4 PGRMC1 SGTA SGTB
Entrez ID		93107	23630
HPRD ID		16253	02268
Ensembl ID		ENSG00000168418	ENSG00000176076
Uniprot IDs		Q32MC1 Q547S7 Q8TDN1	Q9UJ90
PDB IDs
Enriched GO Terms of Interacting Partners?		Potassium Channel Regulator Activity Voltage-gated Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Potassium Ion Transport Delayed Rectifier Potassium Channel Activity Regulation Of Membrane Potential Export Across Plasma Membrane Potassium Channel Activity Metal Ion Transport Regulation Of Potassium Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Complex Transmembrane Transporter Binding Monoatomic Ion Channel Activity Monoatomic Ion Transport Positive Regulation Of Norepinephrine Secretion Protein Homooligomerization Clustering Of Voltage-gated Potassium Channels Transmembrane Transport Determination Of Pancreatic Left/right Asymmetry Protein Complex Oligomerization Cilium Assembly Negative Regulation Of Potassium Ion Export Across Plasma Membrane Determination Of Liver Left/right Asymmetry Protein-containing Complex Assembly Positive Regulation Of Long-term Synaptic Depression Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Determination Of Digestive Tract Left/right Asymmetry Cilium Organization Proximal Dendrite Protein-containing Complex Organization Atrial Cardiac Muscle Cell Action Potential Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion Regulation Of Transport Cholinergic Synapse Neuronal Ion Channel Clustering Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Regulation Of Metal Ion Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Regulation Of Potassium Ion Export Across Plasma Membrane	TRC Complex Protein Homooligomerization Protein Complex Oligomerization Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Localization Within Membrane Dendrite Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Localization Positive Regulation Of Response To Endoplasmic Reticulum Stress Potassium Channel Regulator Activity Glutamate Receptor Signaling Pathway Positive Regulation Of Establishment Of Protein Localization Voltage-gated Potassium Channel Activity Neuron Projection Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Insertion Into Membrane Potassium Channel Activity Voltage-gated Potassium Channel Complex Protein Targeting To Membrane Cell Body Regulation Of Membrane Potential Regulation Of Protein Transport Regulation Of Response To Endoplasmic Reticulum Stress Associative Learning Protein-folding Chaperone Binding Acetylcholine Receptor Activator Activity Protein-containing Complex Assembly Lipoprotein Particle Positive Regulation Of Protein Import Action Potential PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Establishment Of Protein Localization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Memory Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization GET Complex
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