GPR52 and QSOX1

Data Source: HiPPIP (Novel)

		GPR52	QSOX1
Name		G protein-coupled receptor 52	quiescin sulfhydryl oxidase 1
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Platelet Alpha Granule Lumen Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Photoreceptor Activity	Protein Disulfide Isomerase Activity Oxidoreductase Activity Flavin-dependent Sulfhydryl Oxidase Activity Thiol Oxidase Activity FAD Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phototransduction Locomotory Behavior Response To Xenobiotic Stimulus Detection Of Visible Light Cellular Response To Light Stimulus	Protein Folding Negative Regulation Of Macroautophagy Extracellular Matrix Assembly
Pathways		None	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
GWAS		No GWAS studies recorded	Anorexia nervosa ( 23568457 ) Pulse pressure ( 30224653 30578418 )
Novel Interactors		1 novel interactors: QSOX1	9 novel interactors: AKIP1 CREG1 GPR52 GREM2 KIF5B PHAF1 PRRX1 SERPINC1 TNR
Interacting Genes		1 interacting genes: POT1	7 interacting genes: BEGAIN CCR1 CCR6 CHRM4 SHANK3 UBE2D2 UBQLN4
Entrez ID		9293	5768
HPRD ID		07247	06785
Ensembl ID		ENSG00000203737	ENSG00000116260
Uniprot IDs		F2YGU0 Q9Y2T5	A0A140VKE5 O00391
PDB IDs		6LI0 6LI1 6LI2 6LI3 8HMP	3LLI 3LLK 3Q6O 4IJ3
GO Terms Enriched among Interactors		Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Flavin-dependent Sulfhydryl Oxidase Activity Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Thiol Oxidase Activity Shelterin Complex Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere DEAD/H-box RNA Helicase Binding Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Regulation Of DNA Strand Elongation Protein Disulfide Isomerase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Extracellular Matrix Assembly Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding RNA-templated DNA Biosynthetic Process Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening FAD Binding Negative Regulation Of Macroautophagy Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Tertiary Granule Lumen Regulation Of Telomere Maintenance Via Telomere Lengthening Specific Granule Lumen Platelet Alpha Granule Lumen Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Maintenance Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance	G Protein-coupled Receptor Activity Chemokine Receptor Activity Dendritic Cell Migration Dendritic Cell Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Synaptic Transmission Regulation Of Neuron Projection Regeneration Positive Regulation Of Synaptic Transmission, Glutamatergic