NEK9 and IFT43

		NEK9	IFT43
Description		NIMA related kinase 9	intraflagellar transport 43
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol	Cytoplasm Centriole Cytoskeleton Cilium Microtubule Cytoskeleton Intraciliary Transport Particle A Centriolar Satellite Ciliary Basal Body Cell Projection Intercellular Bridge Mitotic Spindle Ciliary Tip
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Cell Projection Organization Intraciliary Retrograde Transport Cilium Assembly
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Intraflagellar transport
Drugs		Fostamatinib
Diseases
GWAS		Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Carpal tunnel syndrome ( 30833571) Emotional lability in attention deficit hyperactivity disorder ( 31085060)
Interacting Genes		16 interacting genes: BICD2 CSN2 GABARAP MAP1LC3A MAP1LC3B MBP NEK6 NEK7 NEK8 PELI2 RAN SSRP1 SUPT16H TTN UBC WEE2-AS1	2 interacting genes: LMO2 ZMYND10
Entrez ID		91754	112752
HPRD ID		11386	14449
Ensembl ID		ENSG00000119638	ENSG00000119650
Uniprot IDs		A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19	Q96FT9
PDB IDs		3ZKE 3ZKF	8BBE 8BBG 8FGW
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein-containing Complex Disassembly FACT Complex Organelle Assembly Autophagosome Maturation Ubiquitin Protein Ligase Binding Autophagosome Membrane Mitophagy Structural Constituent Of Myelin Sheath Microtubule Protein Serine Kinase Activity Autophagy Of Mitochondrion Autophagosome Protein Serine/threonine Kinase Activity Cellular Component Assembly Autophagosome Assembly Nucleosome Disassembly Microtubule Cytoskeleton Organization Protein-DNA Complex Disassembly Autophagosome Organization Endomembrane System Protein-containing Complex Organization Protein Kinase Activity Phospholipid Binding Cytoskeleton Microtubule-based Process Nucleosome Binding Positive Regulation Of Metalloendopeptidase Activity Protein Localization To Myelin Sheath Abaxonal Region DRM Complex Macroautophagy Spindle Organization Kinase Activity Pyroptotic Inflammatory Response Organelle Membrane Vacuole Organization	Positive Regulation Of Motile Cilium Assembly
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