CATSPERH and EDA2R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CATSPERH	EDA2R
Description		catsper channel auxiliary subunit eta	ectodysplasin A2 receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Motile Cilium CatSper Complex Cell Projection	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process		Epidermis Development Ectodermal Cell Differentiation Cytokine-mediated Signaling Pathway Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			TNFs bind their physiological receptors
Drugs
Diseases
GWAS			Balding ( 26926045) Male-pattern baldness ( 22032556 27182965 28196072)
Interacting Genes		13 interacting genes: AQP6 CD3G CD79A EDA2R EMP1 FFAR2 GPR42 KLRC1 MANBAL PSCA SHISAL1 SLC10A6 UPK1B	16 interacting genes: AGR3 ATP6V0C C1QB CASP8 CATSPERH CEBPE EDA FADD GIMAP5 JAGN1 NKG7 PLP1 SGTA STRIT1 TRAF3 TRAF6
Entrez ID		100130348	60401
HPRD ID			02230
Ensembl ID		ENSG00000187066	ENSG00000131080
Uniprot IDs		E9PQX1	B2RBZ9 B4DQY6 Q9HAV5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Nitrate Transmembrane Transporter Activity Inhibitory MHC Class Ib Receptor Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Adaptive Immune Response Positive Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Gamma-delta T Cell Receptor Complex IgM B Cell Receptor Complex Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Apical Plasma Membrane Urothelial Plaque External Side Of Plasma Membrane Plasma Membrane B Cell Receptor Complex Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Ectodermal Cell Differentiation Bile Acid:sodium Symporter Activity	Tumor Necrosis Factor Receptor Binding Death Receptor Binding Defense Response Death Effector Domain Binding Response To External Biotic Stimulus Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Myeloid Leukocyte Differentiation Death-inducing Signaling Complex Leukocyte Differentiation Regulation Of Proteolysis Positive Regulation Of Myeloid Leukocyte Differentiation TRAIL-activated Apoptotic Signaling Pathway CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Signaling Adaptor Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Myeloid Cell Differentiation Positive Regulation Of Macrophage Differentiation Endosome Membrane Negative Regulation Of Necroptotic Process Positive Regulation Of Myeloid Cell Differentiation Cytoplasmic Side Of Plasma Membrane Immune System Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Response To Stress Regulation Of Myeloid Leukocyte Differentiation Mononuclear Cell Differentiation Tube Formation Regulation Of Macrophage Differentiation Innate Immune Response Granulocyte Differentiation Regulation Of Necroptotic Process Response To Other Organism Defense Response To Symbiont Regulation Of Programmed Necrotic Cell Death Cytokine-mediated Signaling Pathway Defense Response To Other Organism Immune Response Toll-like Receptor 4 Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Innate Immune Response Macrophage Differentiation Regulation Of Defense Response Positive Regulation Of Leukocyte Differentiation
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