MTRFR and RFLNA

		MTRFR	RFLNA
Description		mitochondrial translation release factor in rescue	refilin A
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Cytoskeleton Actin Filament Bundle
	Molecular Function	TRNA Binding RNA Binding Translation Release Factor Activity Protein Binding Translation Release Factor Activity, Codon Specific Ribosomal Large Subunit Binding	Protein Binding Filamin Binding
	Biological Process	Translation Translational Termination Rescue Of Stalled Ribosome	Skeletal System Morphogenesis Regulation Of Chondrocyte Development Negative Regulation Of Chondrocyte Development Actin Filament Bundle Organization Negative Regulation Of Bone Mineralization Involved In Bone Maturation
Pathways		Mitochondrial ribosome-associated quality control
Drugs
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS			Hallux valgus ( 32131869) Optic cup area ( 31798171) Osteoarthrosis (time to event) ( 32589924) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535)
Interacting Genes		2 interacting genes: APP CDK2	3 interacting genes: FBXW7 FDFT1 FLNA
Entrez ID		91574	144347
HPRD ID		08791	14066
Ensembl ID		ENSG00000130921	ENSG00000178882
Uniprot IDs		Q9H3J6	Q6ZTI6
PDB IDs		7A5H
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Reproductive Process Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Chromatin Organization Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Initiation Of Neural Tube Closure Midbrain-hindbrain Boundary Morphogenesis Fourth Ventricle Development Negative Regulation Of Chondrocyte Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling X Chromosome Histone H3K36me/H3K36me2 Demethylase Activity Negative Regulation Of Bone Mineralization Involved In Bone Maturation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Third Ventricle Development Regulation Of Spontaneous Synaptic Transmission Chromatin Organization NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity	Squalene Synthase [NAD(P)H] Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Farnesyl Diphosphate Metabolic Process Glycoprotein Ib-IX-V Complex Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Protein Localization To Bicellular Tight Junction Protein Stabilization Fc-gamma Receptor I Complex Binding Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Formation Of Radial Glial Scaffolds Tubulin Deacetylation Negative Regulation Of Protein Catabolic Process Myb Complex Establishment Of Sertoli Cell Barrier Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Ubiquitin Recycling Phosphothreonine Residue Binding Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Osteoclast Development Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Translation Release Factor Activity Translation Release Factor Activity, Codon Specific Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Blood Coagulation, Intrinsic Pathway Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Establishment Of Protein Localization Ubiquitin-protein Transferase Activator Activity Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Osteoclast Development Negative Regulation Of Transcription By RNA Polymerase I Regulation Of SREBP Signaling Pathway Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Platelet Activation Regulation Of Protein Catabolic Process Protein Deacetylation Regulation Of Protein Stability Negative Regulation Of Catabolic Process Translational Termination Actin Crosslink Formation Negative Regulation Of Triglyceride Metabolic Process Ribosomal Large Subunit Binding Positive Regulation Of Neuron Migration Regulation Of Hepatocyte Proliferation Apical Dendrite Sertoli Cell Development Protein Localization To Cell-cell Junction Regulation Of Triglyceride Biosynthetic Process
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