BTF3L4 and SMYD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BTF3L4	SMYD2
Description		basic transcription factor 3 like 4	SET and MYND domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	RNA Polymerase II Complex Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Heart Development Negative Regulation Of Cell Population Proliferation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator
Pathways			PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS			Abdominal aortic aneurysm ( 27899403) Age at first sexual intercourse ( 34211149) Diverticular disease ( 30177863) Rheumatic heart disease ( 34106200) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		5 interacting genes: CEBPA NOTCH3 SMYD2 TXLNA TXLNB	8 interacting genes: BTF3L4 ESR1 H3C14 HSP90AA1 HUNK RB1 SNX11 TP53
Entrez ID		91408	56950
HPRD ID		17521	15406
Ensembl ID		ENSG00000134717	ENSG00000143499
Uniprot IDs		Q96K17	Q9NRG4
PDB IDs			3RIB 3S7B 3S7D 3S7F 3S7J 3TG4 3TG5 4O6F 4WUY 4YND 5ARF 5ARG 5KJK 5KJL 5KJM 5KJN 5V3H 5WCG 6CBX 6CBY 6MON 6N3G 9CKC 9CKF 9CKG
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Syntaxin Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process CHOP-C/EBP Complex Positive Regulation Of Proteolysis Response To Phenylpropanoid Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Glomerular Capillary Formation Neuroblast Differentiation Lysine N-methyltransferase Activity Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Fat Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Histone H3K4 Trimethyltransferase Activity Histone H3K36 Methyltransferase Activity Urea Cycle STAT Family Protein Binding Urea Metabolic Process HMG Box Domain Binding	Disordered Domain Specific Binding Glial Cell Apoptotic Process Nitric-oxide Synthase Regulator Activity Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Response To Salt Stress Muscle Cell Apoptotic Process Negative Regulation Of Glial Cell Proliferation Transcription Regulator Complex Protein Localization To Organelle 14-3-3 Protein Binding Chromatin Remodeling Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Fibroblast Proliferation Response To Antibiotic Regulation Of Chromosome Organization Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Regulation Of Telomere Maintenance Via Telomerase Macromolecule Biosynthetic Process Regulation Of Epithelial Cell Apoptotic Process Transcription Coactivator Binding Response To Xenobiotic Stimulus Regulation Of Telomere Maintenance Via Telomere Lengthening Ubiquitin Protein Ligase Binding Regulation Of Nitric Oxide Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Response To Estrogen Chromatin Organization CTP Binding Chromosome Organization DATP Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Xenobiotic Stimulus Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Intracellular Protein Localization Response To Osmotic Stress Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Ras Protein Signal Transduction Enzyme Binding Regulation Of DNA Biosynthetic Process Regulation Of MiRNA Metabolic Process DNA-templated Transcription Regulation Of Fibroblast Proliferation
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