SLC16A3 and HPCA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC16A3	HPCA
Description		solute carrier family 16 member 3	hippocalcin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Nuclear Membrane Apical Part Of Cell	Cytoplasm Cytosol Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Lactate Transmembrane Transporter Activity Symporter Activity Lactate:proton Symporter Activity Transmembrane Transporter Activity Pyruvate Transmembrane Transporter Activity	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Monocarboxylic Acid Transport Lactate Transport Lactate Transmembrane Transport Plasma Membrane Lactate Transport Pyruvate Catabolic Process Transmembrane Transport Pyruvate Transmembrane Transport	Regulation Of Signal Transduction Calcium-mediated Signaling Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Response To Aroclor 1254 Cellular Response To L-glutamate
Pathways		Basigin interactions Proton-coupled monocarboxylate transport
Drugs		Pyruvic acid
Diseases
GWAS		Hemoglobin ( 32888494) Proteinuria and chronic kidney disease ( 26420894) Refractive error ( 32231278)	Daytime nap ( 33568662)
Interacting Genes		10 interacting genes: BANP BSG CDC42 FAM9B GJA8 HDAC7 HPCA NR2C2AP UBQLN1 UBQLN2	17 interacting genes: AP2B1 C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2
Entrez ID		9123	3208
HPRD ID		04854	00811
Ensembl ID		ENSG00000141526	ENSG00000121905
Uniprot IDs		O15427	P84074
PDB IDs			5G4P 5G58 5M6C 7OWM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Transport GBD Domain Binding Storage Vacuole Regulation Of Endocytosis Regulation Of Receptor Internalization Regulation Of Transmembrane Transporter Activity Response To Ketamine Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Matrix Metallopeptidase Secretion Endothelin Receptor Signaling Pathway Involved In Heart Process Kinase Binding Autophagosome Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Endothelial Cell Migration Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Identical Protein Binding Response To Aroclor 1254 Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process	Phosphocreatine Biosynthetic Process Creatine Kinase Activity
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