UNC5A and NTN1

Number of citations of the paper that reports this interaction (PubMedID 12810718)
0

Data Source:
BioGRID (pull down)

		UNC5A	NTN1
Description		unc-5 netrin receptor A	netrin 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection Membrane Neuronal Cell Body Membrane Cell Projection Neuron Projection Membrane Raft	Extracellular Region Basement Membrane Nucleoplasm Cytoplasm Cytosol Actin Cytoskeleton Synapse Glutamatergic Synapse
	Molecular Function	Netrin Receptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Neuron Projection Development Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway	Neuron Migration Regulation Of Transcription By RNA Polymerase II Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Axonogenesis Axon Guidance Cell Population Proliferation Glial Cell Proliferation Regulation Of Cell Migration Negative Regulation Of Axon Extension Mammary Gland Development Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Positive Regulation Of Glial Cell Proliferation Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Motor Neuron Migration Cell-cell Adhesion Regulation Of Glial Cell Migration Positive Regulation Of Cell Motility
Pathways		Netrin-1 signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 28869591 30598549) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Orofacial clefts ( 33137956) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)
Interacting Genes		3 interacting genes: DAPK1 MAGED1 NTN1	5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		90249	9423
HPRD ID		12131	03368
Ensembl ID		ENSG00000113763	ENSG00000065320
Uniprot IDs		H0Y8R2 Q6ZN44	O95631
PDB IDs		4V2A	4URT 6FKQ 7NDG 7NE0 7NE1
Enriched GO Terms of Interacting Partners?		DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of NMDA Receptor Activity Actin Cytoskeleton Cdc42 Protein Signal Transduction Cellular Response To Hydroperoxide Defense Response To Tumor Cell Chemorepulsion Of Axon Substrate-dependent Cell Migration, Cell Extension Anterior/posterior Axon Guidance Mammary Gland Duct Morphogenesis Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Calcium/calmodulin-dependent Protein Kinase Activity Response To Hydroperoxide Glutamatergic Synapse Regulation Of Neurotransmitter Receptor Activity Syntaxin-1 Binding Motor Neuron Migration Regulation Of Glial Cell Migration Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Glial Cell Proliferation	Anterior/posterior Axon Guidance Neuron Projection Guidance Axon Guidance Netrin Receptor Activity Neuron Projection Development Netrin-activated Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Modulation Of Chemical Synaptic Transmission Netrin Receptor Activity Involved In Chemorepulsion Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Cell Surface Negative Regulation Of Neuron Projection Development Growth Cone Neuron Migration Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Neuron Projection Membrane Negative Regulation Of Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Activity Plasma Membrane Cell Death Apoptotic Process Programmed Cell Death Dorsal Root Ganglion Development Relaxation Of Vascular Associated Smooth Muscle Chemorepulsion Of Axon Positive Regulation Of CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Dendrite Development Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Regulation Of CGMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Collateral Sprouting Co-receptor Binding Negative Regulation Of Axon Regeneration BMP Receptor Binding Negative Regulation Of Neuron Projection Regeneration Trans-synaptic Signaling, Modulating Synaptic Transmission Neuron Projection Positive Regulation Of Mast Cell Degranulation Plasma Membrane Protein Complex Ganglion Development Secretion By Cell Positive Regulation Of Adenylate Cyclase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?