CDKL2 and G3BP2

		CDKL2	G3BP2
Description		cyclin dependent kinase like 2	G3BP stress granule assembly factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome	Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Molecular Condensate Scaffold Activity
	Biological Process	Signal Transduction Sex Differentiation Regulation Of Cell Cycle	Immune System Process Stress Granule Assembly Innate Immune Response MRNA Transport Protein Homooligomerization Positive Regulation Of Stress Granule Assembly
Pathways			SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Fostamatinib
Diseases
GWAS		Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)	HDL cholesterol levels ( 32203549) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)
Interacting Genes		2 interacting genes: APP CBL	68 interacting genes: ANXA1 CEBPA DANCR MDM2 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR19A MIR19B1 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR363 MIR429 MIR7-1 MIR7-2 MIR7-3 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKB1 NFKBIA OGT PDE4B PIN1 PRMT5 RIOK1 TRIM25 USP10 ZNF618
Entrez ID		8999	9908
HPRD ID		16021	06570
Ensembl ID		ENSG00000138769	ENSG00000138757
Uniprot IDs		A0A140VJG1 B4DH08 J3KNE8 Q92772	A0A7I2V3P9 A0A7I2V647 Q9UN86
PDB IDs		4AAA 4BBM 8S6I	5DRV
Enriched GO Terms of Interacting Partners?		Response To Nerve Growth Factor Ephrin Receptor Binding Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Receptor-mediated Endocytosis Acetylcholine Receptor Activator Activity Positive Regulation Of Cellular Component Organization Membrane Raft Amyloid-beta Complex PTB Domain Binding Protein Homooligomerization Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Growth Cone Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Complex Oligomerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Rap Protein Signal Transduction Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Main Axon Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Response To Growth Factor Regulation Of Synapse Structure Or Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Toll Signaling Pathway Regulation Of Endocytosis Ubiquitin-dependent Endocytosis	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of MRNA Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Extracellular Space
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