TNS4 and PIH1D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNS4	PIH1D1
Description		tensin 4	PIH1 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Anchoring Junction	Nucleus Nucleolus Cytoplasm Pre-snoRNP Complex R2TP Complex RPAP3/R2TP/prefoldin-like Complex Ribonucleoprotein Complex
	Molecular Function	Actin Binding Protein Binding	RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Protein Kinase Binding Histone Binding ATPase Binding Phosphoprotein Binding Histone Reader Activity
	Biological Process	Intracellular Protein Localization	Box C/D SnoRNP Assembly Chromatin Remodeling RRNA Processing Epithelial Cell Differentiation SnoRNA Localization Protein Stabilization Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of TORC2 Signaling Positive Regulation Of TORC1 Signaling TORC1 Complex Assembly
Pathways		MET interacts with TNS proteins
Drugs
Diseases
GWAS		Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)
Interacting Genes		23 interacting genes: AR CARD9 CYSRT1 EGFR ERBB3 ERBB4 GAB1 GSTCD HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1	19 interacting genes: BYSL CA4 CDCA7L EAF1 FAM90A1 FARP1 GEM MAPK6 MFAP1 MISP PLEKHN1 RBPMS RCOR3 SCNM1 SEPTIN1 SMARCD1 TNS4 TSC22D4 UBC
Entrez ID		84951	55011
HPRD ID		12223	07938
Ensembl ID		ENSG00000131746	ENSG00000104872
Uniprot IDs		Q6PJP3 Q8IZW8	Q9NWS0
PDB IDs			4PSF 4PSI 6GXZ 7AVC 8BDU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process ErbB-3 Class Receptor Binding Positive Regulation Of Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Eyelid Development In Camera-type Eye Receptor Complex Morphogenesis Of An Epithelial Fold Kinase Activity Negative Regulation Of Programmed Cell Death ATPase Binding Protein Tyrosine Kinase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Viral Transcription Mammary Gland Alveolus Development Suppression Of Viral Release By Host Regulation Of MiRNA Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Positive Regulation Of Metabolic Process Regulation Of Cell Communication Positive Regulation Of Multicellular Organismal Process
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