BUD31 and PANX1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		BUD31	PANX1
Description		BUD31 spliceosome associated protein	pannexin 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Spliceosomal Complex Centrosome Microtubule Cytoskeleton U2-type Catalytic Step 2 Spliceosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Bleb Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding	Protease Binding Actin Binding Signaling Receptor Binding Structural Molecule Activity Gap Junction Channel Activity Monoatomic Anion Channel Activity Calcium Channel Activity ATP Transmembrane Transporter Activity Protein Binding Channel Activity Wide Pore Channel Activity Leak Channel Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of DNA-templated Transcription	Response To Ischemia Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell-cell Signaling ATP Transport Cell Differentiation Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Response To ATP Monoatomic Ion Transmembrane Transport Oogenesis Positive Regulation Of Macrophage Cytokine Production Calcium Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport
Pathways		mRNA Splicing - Major Pathway	Electric Transmission Across Gap Junctions The NLRP3 inflammasome High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs			Probenecid
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620) Serum metabolite levels ( 23093944)	Alanine aminotransferase levels ( 33339817 33547301 34315874) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33339817 33547301 34315874) Autoimmune thyroid disease ( 32581359) Liver enzyme levels (alanine transaminase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		25 interacting genes: ADCY7 APP ATP13A1 BEND5 CCT3 CEBPA CTNNBL1 ERGIC3 HLA-A HOXA1 HTR5A KRTAP10-3 KRTAP10-7 MARCHF6 MEOX2 MMP24 NPC1 PANX1 PICK1 RELB RNF208 SCAF1 SF1 TMEM94 TSPAN7	16 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2
Entrez ID		8896	24145
HPRD ID		10351	10526
Ensembl ID		ENSG00000106245	ENSG00000110218
Uniprot IDs		P41223	Q96RD7
PDB IDs		4OED 4OH6 4OKB 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7AAV 7ABF 7ABG 7ABI 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8QO9 8RO2 9FMD	6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN 7DWB 7F8J 7F8N 7F8O 7WSV 8GTS 8GTT 8GYO
Enriched GO Terms of Interacting Partners?			Sterol Metabolic Process Channel Activity High-density Lipoprotein Particle Binding Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Lipid Catabolic Process Renal Water Homeostasis Disordered Domain Specific Binding Extrinsic Apoptotic Signaling Pathway Multicellular Organismal-level Water Homeostasis Lipoprotein Metabolic Process Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Cytokine Production Involved In Immune Response Sterol Biosynthetic Process Squalene Synthase [NAD(P)H] Activity Response To Fluid Shear Stress Response To Bacterium Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Positive Regulation Of Phagocytosis Peptidyl-methionine Modification Regulation Of Lipid Catabolic Process Cellular Response To Amyloid-beta Alcohol Metabolic Process Extracellular Region High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Catabolic Process Response To Amyloid-beta Lipid Biosynthetic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cholesterol Import Lumenal Side Of Membrane Response To Stress Cellular Response To Mercury Ion Cellular Response To Water Deprivation Multicellular Organismal-level Chemical Homeostasis Glycerol Transmembrane Transporter Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mu-type Opioid Receptor Binding Regulation Of Protein Secretion Positive Regulation Of Bleb Assembly Positive Regulation Of Interleukin-1 Production Regulation Of Amine Transport
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