ZPR1 and CDK5RAP2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZPR1	CDK5RAP2
Description		ZPR1 zinc finger	CDK5 regulatory subunit associated protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Axon Growth Cone Cell Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Gemini Of Cajal Bodies	Pericentriolar Material Spindle Pole Gamma-tubulin Ring Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cell Junction Microtubule Plus-end Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole
	Molecular Function	Protein Binding Zinc Ion Binding Receptor Tyrosine Kinase Binding Translation Initiation Factor Binding Protein Folding Chaperone Metal Ion Binding	Transcription Cis-regulatory Region Binding Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding Protein-containing Complex Binding
	Biological Process	Microtubule Cytoskeleton Organization Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation DNA Replication MRNA Processing Protein Folding Signal Transduction RNA Splicing Positive Regulation Of Gene Expression Spinal Cord Development Cell Differentiation Cajal Body Organization Regulation Of Myelination Positive Regulation Of RNA Splicing DNA Endoreduplication Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Cell Cycle Positive Regulation Of Growth Axon Development Cellular Response To Epidermal Growth Factor Stimulus Apoptotic Process Involved In Development Pre-mRNA Catabolic Process Negative Regulation Of Motor Neuron Apoptotic Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases			Primary microcephaly (MCPH)
GWAS		Aspartate aminotransferase levels ( 33547301) Cholesterol ( 31902109) Coronary artery disease ( 29212778 29263402) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 29403010) Metabolic syndrome ( 30382898 31589552) Myocardial infarction ( 33532862) Postprandial triglyceride levels ( 32603185) Postprandial triglyceride response to high fat diet meal ( 26256467) Total cholesterol levels ( 29615537) Triglyceride levels ( 29615537) Triglyceride levels in HIV infection ( 33109212)	Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)
Interacting Genes		7 interacting genes: CDK5RAP2 EEF1A1 EGFR MPP3 OGT SNUPN SUMO4	26 interacting genes: ABCA2 CDK5 CDK5R1 CLIP4 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LRRK1 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1
Entrez ID		8882	55755
HPRD ID		04877	09740
Ensembl ID		ENSG00000109917	ENSG00000136861
Uniprot IDs		O75312	A0A0A0MRG9 A0A8I5KXG0 A0A8I5QKL1 B3KVI2 B9EG74 Q96SN8
PDB IDs			6X0V 8RX1 9G3Y 9G3Z 9G40 9H9P
Enriched GO Terms of Interacting Partners?		Kinase Binding Clathrin-coated Endocytic Vesicle Membrane Response To Epidermal Growth Factor Regulation Of Protein Catabolic Process Cellular Response To Epidermal Growth Factor Stimulus Multivesicular Body, Internal Vesicle Lumen Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly	Microtubule Cytoskeleton Organization Growth Cone Microtubule-based Process Protein Kinase 5 Complex Cytoskeleton Organization Cerebellum Development Establishment Of Organelle Localization Perikaryon Negative Regulation Of Motor Neuron Apoptotic Process Hippocampus Development Cell Projection Organization ESC/E(Z) Complex Regulation Of Motor Neuron Apoptotic Process Neuromuscular Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Axon Layer Formation In Cerebral Cortex Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cell Projection Regulation Of Nervous System Development Retrograde Axonal Transport Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Plus-end Binding Microtubule Plus-end Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Targeting To Membrane Regulation Of Neuron Apoptotic Process Organelle Localization Regulation Of Microtubule-based Process Regulation Of Intracellular Transport Neuron Projection Regeneration Diol Metabolic Process Neuron Projection Development Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Binding Spinal Cord Development Endopeptidase Regulator Activity Regulation Of Cellular Localization Regulation Of Protein Targeting To Membrane Regulation Of Synapse Organization Organelle Organization Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Postsynapse Organization Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Positive Regulation Of Microtubule Polymerization DNA Endoreduplication Pre-mRNA Catabolic Process Positive Regulation Of Neurotrophin Production
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