ZPR1 and CDK5RAP2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZPR1	CDK5RAP2
Gene Name		ZPR1 zinc finger	CDK5 regulatory subunit associated protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Axon Growth Cone SMN Complex Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Gemini Of Coiled Bodies	Pericentriolar Material Spindle Pole Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Cell Junction Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Receptor Tyrosine Kinase Binding Translation Initiation Factor Binding	Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding
	Biological Process	Microtubule Cytoskeleton Organization Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation MRNA Processing Signal Transduction Cell Proliferation RNA Splicing Positive Regulation Of Gene Expression Spinal Cord Development Cajal Body Organization Regulation Of Myelination Positive Regulation Of RNA Splicing DNA Endoreduplication Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Growth Axon Development Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Apoptotic Process Involved In Development Pre-mRNA Catabolic Process Negative Regulation Of Motor Neuron Apoptotic Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Bundle Formation Organelle Organization Chromosome Segregation Brain Development Neurogenesis Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Centrosome Organization Regulation Of Spindle Checkpoint
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Response to statin therapy ( 20339536)
Protein-Protein Interactions		6 interactors: CDK5RAP2 EEF1A1 EGFR MPP3 SNUPN SUMO4	24 interactors: ABCA2 C14orf1 CDK5 CDK5R1 CRMP1 EEF1G FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1
Entrez ID		8882	55755
HPRD ID		04877	09740
Ensembl ID			ENSG00000136861
Uniprot IDs		O75312	B3KVI2 B9EG74 Q7Z3M0 Q96SN8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Alkanesulfonate Metabolic Process SnRNA Import Into Nucleus RNA Import Into Nucleus Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Negative Regulation Of Centriole Replication Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation	Serine Phosphorylation Of STAT3 Protein Regulation Of Protein Binding Serine Phosphorylation Of STAT Protein Regulation Of Microtubule-based Process Retrograde Axon Cargo Transport Regulation Of Intracellular Transport Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Cycle Process Regulation Of Binding Limbic System Development Regulation Of Neuron Death Regulation Of Organelle Organization Axon Development Cerebellum Development Microtubule-based Movement Cellular Component Assembly Metencephalon Development Negative Regulation Of Axon Extension Movement Of Cell Or Subcellular Component Anterograde Axon Cargo Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Axonogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Protein Transport Hindbrain Development Microtubule-based Process Layer Formation In Cerebral Cortex Positive Regulation Of Receptor Activity Nervous System Development Neuron Projection Development Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Morphogenesis Peptidyl-threonine Phosphorylation Negative Regulation Of Neuron Death Cell Projection Morphogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Pre-mRNA Catabolic Process DNA Endoreduplication Regulation Of Cell Projection Organization Cell Part Morphogenesis Axon Cargo Transport Regulation Of Cytoskeleton Organization Response To Organic Cyclic Compound Positive Regulation Of Intracellular Transport Regulation Of Cell Cycle Organelle Organization
Tagcloud ?			acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Difference) ?			acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Intersection) ?