FGF16 and DVL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FGF16	DVL3
Description		fibroblast growth factor 16	dishevelled segment polarity protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Chromatin Cytoplasm Cytosol
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Small GTPase Binding
	Biological Process	Regulation Of Endothelial Cell Proliferation Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Temperature Stimulus Animal Organ Morphogenesis Neurogenesis Regulation Of Cell Migration Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Small GTPase-mediated Signal Transduction Response To Xenobiotic Stimulus Wnt Signaling Pathway Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Neuron Projection Arborization
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Height ( 31562340)	Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)
Interacting Genes		10 interacting genes: APP CLP1 DVL3 HOOK2 INCA1 KRT31 MCC MFHAS1 PICK1 PTX3	166 interacting genes: ABT1 ADAP1 AKAP17A ANKRD36B AP3M1 AXIN1 BAHD1 BEND7 BHLHE40 C1orf35 C8orf33 CBX8 CCDC33 CCNK CCNL1 CDYL2 CEP57L1 CEP70 CEP76 CLK1 CSNK1D CSNK1E CSNK2A1 CT45A10 CT45A3 CTNNB1 CYSRT1 DAB2 DDX54 DIDO1 DPPA2 DVL1 DYRK1A EIF1B EIF3D ENKD1 FAM13C FAM90A1 FARS2 FGF16 FLACC1 GADD45GIP1 HOMER3 HOXA5 HOXC5 HOXC8 INO80B KAT7 KAZN KCTD10 KCTD7 KLF1 KLF15 KLF3 KLF4 KLHL12 LENG8 LNX1 LONRF1 LRRK2 LUZP4 LY6H MAB21L3 MAGEB4 MAGOHB MARK2 MATN2 MBD1 NFYA NKD1 NOL12 NXF1 PATZ1 PHF19 PIK3CB PITX1 PLAGL2 PLN PNKP PPM1A PPP1R16B PPP2CA PRKAA2 PRPF18 PRPF3 PRPF31 PRPF38A PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSME3 PSMF1 RBM15B RBM39 RNF151 RPL11 RPS10 RRP8 RWDD2B SAP30L SHFL SNIP1 SNX22 SORBS3 STOM SUV39H1 SYT6 SYTL4 TBPL1 TCEA2 TCEANC TFG THAP7 TLE5 TNFAIP8L1 TNP1 TPTEP2-CSNK1E TRAF2 TRIM41 TRIM54 TSN TSPYL1 TSPYL6 UTP3 VANGL1 VAX1 WDR25 WT1 XPA YTHDC1 ZBTB24 ZBTB26 ZBTB47 ZBTB48 ZBTB8A ZFP57 ZNF165 ZNF2 ZNF264 ZNF319 ZNF408 ZNF417 ZNF441 ZNF444 ZNF497 ZNF512B ZNF552 ZNF581 ZNF648 ZNF696 ZNF697 ZNF699 ZNF71 ZNF764 ZNF774 ZNF775 ZNF792 ZNF821 ZNF837 ZRSR2 ZSCAN21 ZSCAN22 ZSCAN25
Entrez ID		8823	1857
HPRD ID		04764	03222
Ensembl ID		ENSG00000196468	ENSG00000161202
Uniprot IDs		O43320	Q92997
PDB IDs			6V7O 6ZBQ 6ZBZ 6ZC3 6ZC4 6ZC6 6ZC7 6ZC8 8S6A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JNK Cascade Response To Yeast Regulation Of JNK Cascade Positive Regulation Of Endocytosis Positive Regulation Of Receptor Internalization Neuron Projection Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Frizzled Binding Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Response To Fungus Glial Cell Development Regulation Of Nitric Oxide Metabolic Process Regulation Of Endocytosis G Protein-coupled Receptor Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Receptor Internalization Positive Regulation Of Protein Import Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity Regulation Of Protein Localization PTB Domain Binding Signaling Receptor Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Global Gene Silencing By MRNA Cleavage Trans-Golgi Network Membrane Identical Protein Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of MAPK Cascade Cellular Response To Norepinephrine Stimulus	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Wnt Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Speck Cellular Response To Endothelin Response To Endothelin Negative Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Epigenetic Regulation Of Gene Expression Wnt Signalosome Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm RNA Metabolic Process Chromatin Organization Nucleic Acid Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sequence-specific Double-stranded DNA Binding Heterochromatin Formation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Chromatin Remodeling U2-type Precatalytic Spliceosome Chromatin Silencing Complex Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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