ABCC3 and HLF

		ABCC3	HLF
Description		ATP binding cassette subfamily C member 3	HLF transcription factor, PAR bZIP family member
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Ciliary Basal Body	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity Glucuronoside Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ABC-type Bile Acid Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Icosanoid Transmembrane Transporter Activity ABC-type Transporter Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Bile Acid And Bile Salt Transport Glucuronoside Transport Xenobiotic Transport Carboxylic Acid Transport Transmembrane Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways		Recycling of bile acids and salts ABC-family proteins mediated transport Aspirin ADME Paracetamol ADME NFE2L2 regulating MDR associated enzymes
Drugs
Diseases
GWAS			Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Bipolar disorder ( 31043756 33263727) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Urate levels ( 23263486 31578528 31985003) Urate levels in obese individuals ( 25811787) Waist circumference ( 28552196) Weight ( 28552196) Zinc levels ( 26025379)
Interacting Genes		2 interacting genes: MLH1 MTDH	6 interacting genes: BMAL1 CREBBP DBP HNF4G MYB TET2
Entrez ID		8714	3131
HPRD ID		06826	00797
Ensembl ID		ENSG00000108846	ENSG00000108924
Uniprot IDs		O15438 Q86VN9	Q16534
PDB IDs		8HVH 8HW2 8HW4 8IZP
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Chiasma Late Recombination Nodule Mismatch Repair Complex Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Common Bile Duct Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Detection Of Nodal Flow Positive Regulation Of Isotype Switching To IgA Isotypes Intercellular Canaliculus MutSalpha Complex Binding Regulation Of Mitotic Recombination Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Spindle Midzone Assembly Somatic Diversification Of Immune Receptors Via Somatic Mutation MKS Complex Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Left/right Axis Specification Regulation Of Isotype Switching To IgG Isotypes	Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Golgi Vesicle Docking Icosanoid Transmembrane Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport Energy Homeostasis Histone H3K27 Acetyltransferase Activity Positive Regulation Of Hepatic Stellate Cell Proliferation Myosin II Heavy Chain Binding Oxidative Stress-induced Premature Senescence Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Testosterone Secretion DNA 5-methylcytosine Dioxygenase Activity
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