TSLP and CRLF2

Number of citations of the paper that reports this interaction (PMID 11418668)
74

Data Source:
HPRD (in vivo)

		TSLP	CRLF2
Gene Name		thymic stromal lymphopoietin	cytokine receptor-like factor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity
	Biological Process
Pathways
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096) Asthma ( 21804548 21804549) Eosinophil counts ( 19198610)
Protein-Protein Interactions		7 interactors: APP CRLF2 IKBKG IL7R PRNP STAT3 STAT5A	3 interactors: IL7R JAK2 TSLP
Entrez ID		85480	64109
HPRD ID		06108	02288
Ensembl ID		ENSG00000145777	ENSG00000205755
Uniprot IDs		G3XAM8 Q969D9	D0E2W4 Q5G7M1 Q9HC73
PDB IDs
Enriched GO Terms of Interacting Partners?		Homeostatic Process Regulation Of Multicellular Organism Growth Cellular Copper Ion Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Copper Ion Homeostasis Intracellular Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Positive Regulation Of Gene Expression Cellular Response To Growth Hormone Stimulus Homeostasis Of Number Of Cells Regulation Of Activated T Cell Proliferation Response To Growth Hormone Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Developmental Growth Regulation Of T Cell Activation Negative Regulation Of Cell Death JAK-STAT Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Immunoglobulin Production Regulation Of Lymphocyte Activation Lymphocyte Homeostasis Inflammatory Response Anatomical Structure Morphogenesis Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Differentiation Leukocyte Homeostasis Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mast Cell Differentiation Defense Response Positive Regulation Of Lymphocyte Differentiation Feeding Behavior Regulation Of Cytokine Production Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Gene Expression Cellular Response To Cytokine Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Behavior Regulation Of Cell Death Regulation Of T Cell Differentiation Regulation Of Growth Regulation Of Cell Adhesion Regulation Of Cell Differentiation	Host Programmed Cell Death Induced By Symbiont Histone H3-Y41 Phosphorylation Homeostasis Of Number Of Cells Interleukin-7-mediated Signaling Pathway Mineralocorticoid Receptor Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Interleukin-12-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Cytokine-mediated Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway STAT Protein Import Into Nucleus Negative Regulation Of T Cell Mediated Cytotoxicity Response To Interleukin-12 Regulation Of Cell Activation Tyrosine Phosphorylation Of Stat3 Protein Activation Of Janus Kinase Activity Cellular Response To Cytokine Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Cell Adhesion Hemopoiesis Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Immune System Development Response To Cytokine Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Differentiation Regulation Of Immune Response Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Response To Hydroperoxide Negative Regulation Of Heart Contraction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Growth Hormone Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of Interleukin-1 Beta Production Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Tagcloud ?		7r abs added b220 contributions cultures cytokine employed fact failed idea igm immature jak1 jak3 janus kinases lymphopoiesis lymphopoietin mabs make nag8 overlap plated semisolid stat5 stromal thymic uses	acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il15ra il1a il1b il23a il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7
Tagcloud (Difference) ?		7r abs added b220 contributions cultures cytokine employed fact failed idea igm immature jak1 jak3 janus kinases lymphopoiesis lymphopoietin mabs make nag8 overlap plated semisolid stat5 stromal thymic uses	acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il15ra il1a il1b il23a il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7
Tagcloud (Intersection) ?