TSLP and CRLF2

Number of citations of the paper that reports this interaction (PubMedID 11418668)
0

Data Source:
HPRD (in vivo)

		TSLP	CRLF2
Description		thymic stromal lymphopoietin	cytokine receptor like factor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-7 Receptor Binding	Cytokine Receptor Activity Coreceptor Activity Cytokine Binding
	Biological Process	Positive Regulation Of Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Activation Interleukin-7-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Fungus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Chemokine (C-C Motif) Ligand 1 Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Receptor Signaling Pathway Via STAT	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-5 Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		Interleukin-7 signaling Interleukin-7 signaling	Interleukin-7 signaling Interleukin-7 signaling
Drugs		Tezepelumab
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 22036096) Allergic sensitization ( 23817571) Asthma ( 31959851 31619474 31361310 32296059 30929738 29785011 29273806 21804548 21804549 27611488 27182965 34103634) Asthma (adult onset) ( 30929738 31036433) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eosinophil count ( 32888494 19198610 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 34506852 25407941 25017104) Eosinophilic granulomatosis with polyangiitis ( 31719529) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Self-reported allergy ( 23817569)
Interacting Genes		8 interacting genes: APP CRLF2 FBXO7 IKBKG IL7R PRNP STAT3 STAT5A	3 interacting genes: IL7R JAK2 TSLP
Entrez ID		85480	64109
HPRD ID		06108	02288
Ensembl ID		ENSG00000145777	ENSG00000205755
Uniprot IDs		Q969D9	Q9HC73
PDB IDs		5J11 5J12 5J13 8QFZ	5J11 5J12
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Regulation Of Cell Activation Positive Regulation Of Gene Expression Regulation Of Multicellular Organism Growth Lymphocyte Homeostasis Homeostatic Process Interleukin-7-mediated Signaling Pathway Leukocyte Homeostasis Interleukin-9-mediated Signaling Pathway Regulation Of Apoptotic Process Interleukin-15-mediated Signaling Pathway Regulation Of Programmed Cell Death External Side Of Plasma Membrane Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Cytokine Production Interleukin-2-mediated Signaling Pathway Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Intracellular Copper Ion Homeostasis Regulation Of Immune Response Regulation Of Hemopoiesis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Copper Ion Homeostasis Positive Regulation Of Immune System Process Regulation Of Signal Transduction Immune System Process Multicellular Organismal-level Homeostasis Regulation Of Cell Cycle Cellular Response To Copper Ion Positive Regulation Of Inflammatory Response Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Molecular Function Activator Activity Negative Regulation Of Immune System Process Negative Regulation Of Lymphocyte Activation Positive Regulation Of Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process Leukocyte Activation	Positive Regulation Of Receptor Signaling Pathway Via STAT Interleukin-7-mediated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Interleukin-35-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 1 Production Positive Regulation Of Immune System Process T Cell Differentiation Immune Response Response To Other Organism Positive Regulation Of Gene Expression Hemopoiesis Interleukin-7 Receptor Activity Regulation Of Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Interleukin-7 Receptor Binding Defense Response Response To External Biotic Stimulus Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Interleukin-12 Receptor Complex Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of T Cell Activation Lymphocyte Differentiation Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Response To Interleukin-12 Interleukin-23 Receptor Complex Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Activation Of Janus Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Positive Regulation Of Multicellular Organismal Process Defense Response To Bacterium
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