DCLK3 and RAMP1

Number of citations of the paper that reports this interaction (PubMedID 20099900)
0

Data Source:
BioGRID (pull down)

		DCLK3	RAMP1
Description		doublecortin like kinase 3	receptor activity modifying protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Plasma Membrane Cell Surface Membrane Receptor Complex CGRP Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Calcitonin Gene-related Peptide Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Calcitonin Gene-related Peptide Binding
	Biological Process	Protein Localization To Nucleus	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane Amylin Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways			G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs		Fostamatinib	Pramlintide
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Chronotype ( 30696823) Morning person ( 30696823) Schizophrenia ( 28991256) Takayasu arteritis ( 25604533) White matter hyperintensity volume ( 32062564)	Obesity-related traits ( 23251661) Resting metabolic rate ( 28476931)
Interacting Genes		2 interacting genes: ADM RAMP1	10 interacting genes: CALCA CALCR CALCRL DCLK3 IAPP MAL MS4A13 NKG7 SLC31A2 VIPR1
Entrez ID		85443	10267
HPRD ID		19338	05515
Ensembl ID		ENSG00000163673	ENSG00000132329
Uniprot IDs		A0A1B0GTZ4 Q9C098	E9PC20 O60894
PDB IDs			2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y 6UMG 6ZHO 6ZIS 7KNT 7KNU 7P0F 7P0I 7TYF 7TYW 8AX5 8AX6 8AX7 9AUC
Enriched GO Terms of Interacting Partners?		Calcitonin Family Receptor Signaling Pathway Receptor Internalization Adrenomedullin Receptor Binding Positive Regulation Of Progesterone Biosynthetic Process Calcitonin Gene-related Peptide Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis CGRP Receptor Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Progesterone Biosynthetic Process Amylin Receptor 1 Signaling Pathway Positive Regulation Of Protein Glycosylation Amylin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Adrenomedullin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Regulation Of Protein Glycosylation Positive Regulation Of Hormone Biosynthetic Process Vascular Associated Smooth Muscle Cell Development Endocytosis Antifungal Humoral Response Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Vasculogenesis G Protein-coupled Receptor Internalization Negative Regulation Of Vasoconstriction Response To Yeast Regulation Of Vasculogenesis Negative Regulation Of Vascular Permeability Positive Regulation Of Glycoprotein Biosynthetic Process Regulation Of Urine Volume Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Hormone Biosynthetic Process Import Into Cell Regulation Of Ketone Biosynthetic Process Positive Regulation Of Heart Rate G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Heart Contraction Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Vascular Permeability Defense Response To Fungus Coreceptor Activity Response To Fungus Antibacterial Humoral Response Vasculogenesis	Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Receptor Activity Amylin Receptor 3 Signaling Pathway Calcitonin Gene-related Peptide Receptor Activity Negative Regulation Of Bone Resorption G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Bone Remodeling Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Transmembrane Signaling Receptor Activity Regulation Of Bone Remodeling Regulation Of CAMP/PKA Signal Transduction Osteoclast Differentiation Negative Regulation Of Myeloid Leukocyte Differentiation Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Regulation Of Copper Ion Transmembrane Transport Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Sucrose Stimulus Regulation Of Osteoclast Differentiation Receptor Internalization Regulation Of Tissue Remodeling Calcitonin Receptor Binding Amyloid-beta Binding Amylin Receptor Complex 3 G Protein-coupled Receptor Activity Adrenomedullin Binding CGRP Receptor Complex Negative Regulation Of Myeloid Cell Differentiation Regulation Of Calcium-mediated Signaling Amylin Receptor Activity Membrane Raft Polarization Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Hormone Activity
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