DNAJC14 and LYST

Number of citations of the paper that reports this interaction (PubMedID 11984006)
0

Data Source:
HPRD (in vitro)

		DNAJC14	LYST
Description		DnaJ heat shock protein family (Hsp40) member C14	lysosomal trafficking regulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Microtubule Cytoskeleton
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding Dopamine Receptor Binding	Protein Binding
	Biological Process	Protein Transport	Lymphocyte Mediated Immunity Phagocytosis Immune Response Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus Defense Response To Other Organism
Pathways
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Refractive error ( 32231278)	Basophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 19838195 26502338)
Interacting Genes		5 interacting genes: ADRB2 AGTR1 BTG3 DRD1 LYST	23 interacting genes: ATN1 CALM1 CELF4 CNTROB CPAP CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ ZNF521
Entrez ID		85406	1130
HPRD ID		12082	06060
Ensembl ID		ENSG00000135392	ENSG00000143669
Uniprot IDs		Q6Y2X3	Q99698
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Vessel Diameter Maintenance Regulation Of Tube Size Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Vascular Process In Circulatory System Temperature Homeostasis Regulation Of Systemic Arterial Blood Pressure Circulatory System Process Smooth Muscle Contraction Vasodilation G Protein-coupled Receptor Activity Endosome To Lysosome Transport Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Angiotensin Type I Receptor Activity Lysosomal Transport Beta2-adrenergic Receptor Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Binding Mast Cell Secretory Granule Organization Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G Protein-coupled Receptor Complex Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Conditioned Taste Aversion Sensitization Vacuolar Transport Regulation Of Blood Pressure Response To Psychosocial Stress Muscle Contraction Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Cell Chemotaxis Cell Migration Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Habituation Operant Conditioning Dopamine Neurotransmitter Receptor Activity Muscle System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagosome Maturation Microtubule Cytoskeleton Heat Generation	Protein Domain Specific Binding Regulation Of Receptor Signaling Pathway Via JAK-STAT Calcium Channel Inhibitor Activity Astral Microtubule Organization Ribonucleoprotein Complex Alternative MRNA Splicing, Via Spliceosome Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Multivesicular Body Organization Multivesicular Body Assembly Centriole Assembly
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