ANXA11 and ALG2

Number of citations of the paper that reports this interaction (PubMedID 20691033)
50

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		ANXA11	ALG2
Description		annexin A11	ALG2 alpha-1,3/1,6-mannosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Vesicle Membrane Membrane Midbody Extracellular Matrix Melanosome Specific Granule Azurophil Granule Phagocytic Vesicle Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Phosphatidylserine Binding RNA Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylethanolamine Binding MHC Class II Protein Complex Binding S100 Protein Binding Calcium-dependent Protein Binding	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity
	Biological Process	Phagocytosis Cytokinetic Process Cell Division Response To Calcium Ion	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways			Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG2 causes CDG-1i
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Diabetic kidney disease ( 26305897) Sarcoidosis ( 22936702 32826979) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848)	Asthma ( 31959851 34103634) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		19 interacting genes: ALG2 ARSA CDC42 CEP55 ENO2 EWSR1 FUBP1 HNRNPH3 KRTAP13-2 KRTAP6-2 NFKBID OGT PDCD6 PLSCR1 S100A6 SRI TFG WWOX ZDHHC17	4 interacting genes: ANXA11 PEF1 PTPN23 SRI
Entrez ID		311	85365
HPRD ID		03983	09716
Ensembl ID		ENSG00000122359	ENSG00000119523
Uniprot IDs		P50995 Q5T0G8	A0A0A0MTE0 Q9H553
PDB IDs		9FOF 9FOR
Enriched GO Terms of Interacting Partners?		Identical Protein Binding	Calcium-dependent Protein Binding Extracellular Exosome Calcium Ion Binding Positive Regulation Of Homophilic Cell Adhesion Response To Calcium Ion Positive Regulation Of Adherens Junction Organization Vesicle-mediated Transport Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of Wnt Protein Secretion Regulation Of Adherens Junction Organization Regulation Of Homophilic Cell Adhesion Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Secretion Regulation Of Protein Monoubiquitination Negative Regulation Of Striated Muscle Contraction Chromaffin Granule Membrane Neural Crest Formation Response To Metal Ion Positive Regulation Of Early Endosome To Late Endosome Transport Protein Heterodimerization Activity Azurophil Granule Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Phosphatidylethanolamine Binding S100 Protein Binding Specific Granule Regulation Of Cell Communication By Electrical Coupling Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Regulation Of Protein Transport Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Epithelial Cell Migration COPII Vesicle Coat Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Regulation Of Establishment Of Protein Localization Negative Regulation Of Blood Circulation Regulation Of Cellular Localization Early Endosome To Late Endosome Transport COPII Vesicle Coating MHC Class II Protein Complex Binding Regulation Of Secretion By Cell Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Neural Crest Cell Development Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Cardiac Muscle Cell Contraction Regulation Of Secretion Vesicle Membrane Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
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