ZCCHC3 and IFIH1

Number of citations of the paper that reports this interaction (PubMedID 30193849)
0

Data Source:
BioGRID (pull down)

		ZCCHC3	IFIH1
Description		zinc finger CCHC-type containing 3	interferon induced with helicase C domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Pattern Recognition Receptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Detection Of Virus Positive Regulation Of Type I Interferon Production Innate Immune Response Defense Response To Virus Cellular Response To Exogenous DsRNA Positive Regulation Of RIG-I Signaling Pathway	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Detection Of Virus Response To Virus Protein Sumoylation Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production MDA-5 Signaling Pathway Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Complex Oligomerization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Cellular Response To Virus Antiviral Innate Immune Response
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses Modulation of host responses by IFN-stimulated genes
Drugs
Diseases			Type I diabetes mellitus
GWAS		Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) HDL cholesterol levels ( 32203549) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Psoriasis ( 23143594 25903422 25574825 20953190) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 26502338 28714469 27399966 19838195) Type 1 diabetes ( 17554260 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: IFIH1 OGT	9 interacting genes: APP CCDC50 KEAP1 RNF10 RNF135 TRIM40 TRIM65 USP3 ZCCHC3
Entrez ID		85364	64135
HPRD ID		15701	09507
Ensembl ID		ENSG00000247315	ENSG00000115267
Uniprot IDs		Q9NUD5	Q9BYX4
PDB IDs			2RQB 3B6E 3GA3 4GL2 7DNI 7DNJ 7JL0 7JL2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Regulation Of Type III Interferon Production MDA-5 Signaling Pathway Detection Of Virus Regulation Of Transcription By Glucose NSL Complex Mitophagy Protein Localization To Lysosome Protein Modification Process Circadian Regulation Of Gene Expression Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Glucose Stimulus Acetylglucosaminyltransferase Activity Regulation Of Stem Cell Population Maintenance Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Histone Acetyltransferase Complex Regulation Of Carbohydrate Catabolic Process Mitochondrion Sin3-type Complex Regulation Of Gluconeogenesis Defense Response Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Cellular Response To Carbohydrate Stimulus Regulation Of Necroptotic Process Negative Regulation Of Translational Initiation Positive Regulation Of Gene Expression Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Pyroptotic Inflammatory Response Cellular Response To Nutrient Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagy Of Mitochondrion Positive Regulation Of Translational Initiation Regulation Of Rac Protein Signal Transduction Protein-containing Complex Organization Macromolecule Biosynthetic Process Negative Regulation Of Protein Ubiquitination Protein-containing Complex Assembly	Post-translational Protein Modification Innate Immune Response Positive Regulation Of Type I Interferon Production Protein Modification By Small Protein Conjugation Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Protein Ligase Activity Regulation Of Type I Interferon Production Metal Ion Binding Protein Modification Process Positive Regulation Of Cytokine Production Response To Other Organism Positive Regulation Of Interferon-beta Production Immune Response Protein Metabolic Process Protein Ubiquitination Zinc Ion Binding Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus Glycerol-3-phosphate Dehydrogenase (quinone) Activity Protein Polyubiquitination Defense Response To Virus Regulation Of Interferon-beta Production Protein K63-linked Ubiquitination Regulation Of Cytokine Production Regulation Of Defense Response Antiviral Innate Immune Response Acetylcholine Receptor Activator Activity Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Glycerol-3-phosphate Shuttle Response To Virus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?