DGKE and MKS1

		DGKE	MKS1
Description		diacylglycerol kinase epsilon	MKS transition zone complex subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Glutamatergic Synapse	Nucleoplasm Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Membrane Ciliary Transition Zone MKS Complex Ciliary Basal Body Cell Projection
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerophospholipid Biosynthetic Process Glycerolipid Metabolic Process Lipid Phosphorylation Modulation Of Chemical Synaptic Transmission	Neural Tube Closure Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Left/right Symmetry Regulation Of Smoothened Signaling Pathway Epithelial Structure Maintenance Cell Projection Organization Embryonic Digit Morphogenesis Motile Cilium Assembly Embryonic Skeletal System Development Branching Morphogenesis Of An Epithelial Tube Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Head Development Cardiac Septum Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Common Bile Duct Development Non-motile Cilium Assembly Embryonic Brain Development Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Effects of PIP2 hydrolysis	Hedgehog 'off' state Anchoring of the basal body to the plasma membrane
Drugs		alpha-Tocopherol succinate
Diseases			Meckel syndrome (MKS); Meckel-Gruber syndrome Bardet-Biedl syndrome (BBS)
GWAS		Crohn's disease ( 28067908) Early spontaneous preterm birth ( 31194736) Height ( 18391951) Refractive error ( 32231278) Retinal detachment or retinal break ( 31816047)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		2 interacting genes: HRAS MRPL44	3 interacting genes: DDX24 RNF34 TMEM67
Entrez ID		8526	54903
HPRD ID		03259	07900
Ensembl ID		ENSG00000153933	ENSG00000011143
Uniprot IDs		A1L4Q0 P52429	A0A7I2V2M0 B4DVC5 H0Y2S2 J3KSC6 Q9NXB0
PDB IDs
Enriched GO Terms of Interacting Partners?		Phospholipase C Activator Activity Ciliary Basal Body GTPase Complex Common Bile Duct Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Ribonuclease III Activity Mitochondrial Translational Elongation Oncogene-induced Cell Senescence	Icosanoid Transmembrane Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport AV Node Cell To Bundle Of His Cell Signaling Response To Nickel Cation Low Voltage-gated Calcium Channel Activity Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Signaling Macromolecule Catabolic Process Wnt Receptor Catabolic Process Regulation Of Oxygen Metabolic Process Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential ABC-type Bile Acid Transporter Activity SA Node Cell To Atrial Cardiac Muscle Cell Communication AV Node Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential SA Node Cell Action Potential
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