CDH16 and NDUFS8

Data Source: HiPPIP (Novel)

		CDH16	NDUFS8
Name		cadherin 16	NADH:ubiquinone oxidoreductase core subunit S8
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Synapse Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Respiratory Chain Complex I
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell-cell Adhesion	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		None	Respiratory electron transport Complex I biogenesis
Drugs		None	NADH
Diseases		None	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )	No GWAS studies recorded
Novel Interactors		7 novel interactors: ATP2A3 CDH5 GCM1 MRPL52 NDUFS8 NQO1 TUBB	1 novel interactors: CDH16
Interacting Genes		2 interacting genes: CTNNB1 G6PC1	2 interacting genes: GEM UBC
Entrez ID		1014	4728
HPRD ID		11929	03683
Ensembl ID		ENSG00000166589	ENSG00000110717
Uniprot IDs		O75309	O00217
PDB IDs		Not available	5XTB 5XTD 5XTH 5XTI
GO Terms Enriched among Interactors		Response To Caloric Restriction Transmembrane Transporter Binding Catenin Complex Homeostatic Process Calcium-dependent ATPase Activity Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Endothelial Cell Differentiation Cell Periphery Cell-cell Junction Assembly Protein Phosphatase Binding Cell-cell Adhesion Mediated By Cadherin Adherens Junction Organization Bicellular Tight Junction Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Catenin-TCF7L2 Complex NADH Dehydrogenase (quinone) (non-electrogenic) Activity NADPH Dehydrogenase (quinone) Activity NAD(P)H Dehydrogenase (quinone) Activity Response To Resveratrol Glucose-6-phosphatase Activity Astrocyte Fate Commitment	None