TMEM128 and SLC1A3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TMEM128	SLC1A3
Name		transmembrane protein 128	solute carrier family 1 member 3
Structure		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Cell Periphery Membrane Protein Complex
	Molecular Function	Protein Binding	L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Acidic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Amino Acid Binding Metal Ion Binding
	Biological Process	None	Neurotransmitter Uptake Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Intracellular Sodium Ion Homeostasis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Light Stimulus Gamma-aminobutyric Acid Biosynthetic Process Response To Wounding Neutral Amino Acid Transport L-glutamate Transmembrane Transport Cranial Nerve Development Auditory Behavior Response To Antibiotic Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance L-glutamate Import Transepithelial Transport D-aspartate Import Across Plasma Membrane Cellular Response To Cocaine Potassium Ion Transmembrane Transport Import Into Cell L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport
Pathways		None	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC-mediated transport of amino acids
Drugs		None	Glutamic acid
Diseases		None	Episodic ataxias
GWAS		Glomerular filtration rate ( 24351856 )	Depression in smokers ( 30219690 ) Heel bone mineral density ( 28869591 30598549 ) Intraocular pressure ( 29617998 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lumbar spine bone mineral density (trabecular) ( 27476799 ) Malaria ( 31844061 ) Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		None recorded	1 novel interactors: RFX3
Interacting Genes		66 interacting genes: AQP6 ARL13B BCL2L13 BEST2 CD40 CD53 CD79A CLDN5 CLDN7 CLN8 CPLX4 CREB3L1 CYB561 CYBC1 ELOVL4 ERGIC3 FAM209A FFAR2 GAD2 GJA1 GJA8 GJB5 GORAB GPR152 GPR42 GPX8 HSD17B11 HSD17B13 IER3IP1 IL3RA JAGN1 KCNK5 LEUTX LHFPL2 LHFPL5 LMNA MAPK8IP2 MFF MRPS18B MTERF1 MTIF3 MUC1 REEP4 RETREG3 SCN3B SEC11C SHISAL1 SLC10A6 SLC18A1 SLC1A3 SLC26A6 SLC34A2 SLC35H1 SLC61A1 SLC7A14 SSMEM1 STX1A TMEM106A TMEM237 TMEM45B TMEM52B TMEM80 TMPRSS2 TMX2 ZDHHC15 ZFYVE27	6 interacting genes: BTN2A2 MGST3 SGK1 TMEM120B TMEM128 ZDHHC17
Entrez ID		85013	6507
HPRD ID		17483	02523
Ensembl ID		ENSG00000132406	ENSG00000079215
Uniprot IDs		B7Z3K1 Q5BJH2	A0A087WT87 A0A087X0U3 B4DF14 P43003 Q7Z5T0 Q8N169
PDB IDs		Not available	5LLM 5LLU 5LM4 5MJU 7NPW
GO Terms Enriched among Interactors		Membrane Protein Binding Endoplasmic Reticulum Organization Endoplasmic Reticulum Transmembrane Transport Inorganic Anion Transport Acidic Amino Acid Transport Neurotransmitter Transport Endoplasmic Reticulum Membrane Connexin Complex Steroid Dehydrogenase Activity Organic Anion Transport Gap Junction Channel Activity Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Plasma Membrane Gap Junction Monoatomic Ion Transport Dicarboxylic Acid Transport Neurotransmitter Uptake Gamma-aminobutyric Acid Biosynthetic Process Gamma-aminobutyric Acid Metabolic Process Carboxylic Acid Transport Organic Acid Transport Atrial Cardiac Muscle Cell Action Potential Chloride Transmembrane Transport Chloride Transport L-glutamate Import Across Plasma Membrane Efflux Transmembrane Transporter Activity	None