PIGY and ABCB4

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PIGY	ABCB4
Name		phosphatidylinositol glycan anchor biosynthesis class Y	ATP binding cassette subfamily B member 4
Structure		No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Nucleotide Binding Protein Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity ABC-type Transporter Activity
	Biological Process	GPI Anchor Biosynthetic Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes PFIC3, ICP3 and GBD1
Diseases		None	Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Bipolar disorder ( 22925353 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Alanine aminotransferase levels ( 33547301 33339817 ) Alanine transaminase levels ( 29403010 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Epithelial ovarian cancer ( 25134534 ) Gallbladder cancer ( 28274756 ) Gallstone disease ( 30504769 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean reticulocyte volume ( 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Total cholesterol levels ( 30275531 )
Novel Interactors		None recorded	1 novel interactors: PRKAR2B
Interacting Genes		5 interacting genes: ABCB4 ERG28 FBXO7 PIGA TMEM72	3 interacting genes: HAX1 PIGY TESK1
Entrez ID		84992	5244
HPRD ID		17492	01371
Ensembl ID		ENSG00000255072	ENSG00000005471
Uniprot IDs		Q3MUY2	P21439
PDB IDs		Not available	6S7P 7NIU 7NIV 7NIW
GO Terms Enriched among Interactors		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Cellular Response To Bile Acid Response To Fenofibrate Ceramide Floppase Activity Ceramide Translocation Lewy Body Core Intercellular Canaliculus Positive Regulation Of Phospholipid Translocation Bile Acid Secretion Sphingolipid Translocation Response To Bile Acid Phosphatidylcholine Floppase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Lipid Metabolic Process ATPase-coupled Intramembrane Lipid Transporter Activity Positive Regulation Of Phospholipid Transport Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Response To Antipsychotic Drug Protein Domain Specific Binding CAMP-dependent Protein Kinase Regulator Activity Podocyte Cell Migration Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Actin Filament Organization Lamellipodium Granulocyte Colony-stimulating Factor Signaling Pathway Interleukin-1 Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Granulocyte Differentiation