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FIZ1 and FLT3
Number of citations of the paper that reports this interaction (PubMedID
10409713
)
0
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
FIZ1
FLT3
Description
FLT3 interacting zinc finger 1
fms related receptor tyrosine kinase 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Plasma Membrane
Endosome Membrane
Membrane
Protein-containing Complex
Receptor Complex
Molecular Function
Transcription Coactivator Activity
Zinc Ion Binding
Receptor Tyrosine Kinase Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Vascular Endothelial Growth Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Nuclear Glucocorticoid Receptor Binding
Protein-containing Complex Binding
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
Positive Regulation Of Transcription By RNA Polymerase II
Leukocyte Homeostasis
Myeloid Progenitor Cell Differentiation
Pro-B Cell Differentiation
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Macromolecule Metabolic Process
Cell Migration
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Hemopoiesis
B Cell Differentiation
Common Myeloid Progenitor Cell Proliferation
Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Lymphocyte Proliferation
Protein Autophosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Cytokine Stimulus
Cellular Response To Glucocorticoid Stimulus
Dendritic Cell Differentiation
Liver Regeneration
Pathways
PI3K Cascade
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
FLT3 Signaling
FLT3 Signaling
STAT5 Activation
FLT3 mutants bind TKIs
STAT5 activation downstream of FLT3 ITD mutants
KW2449-resistant FLT3 mutants
semaxanib-resistant FLT3 mutants
crenolanib-resistant FLT3 mutants
gilteritinib-resistant FLT3 mutants
lestaurtinib-resistant FLT3 mutants
midostaurin-resistant FLT3 mutants
pexidartinib-resistant FLT3 mutants
ponatinib-resistant FLT3 mutants
quizartinib-resistant FLT3 mutants
sorafenib-resistant FLT3 mutants
sunitinib-resistant FLT3 mutants
tandutinib-resistant FLT3 mutants
linifanib-resistant FLT3 mutants
tamatinib-resistant FLT3 mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Negative regulation of FLT3
FLT3 signaling through SRC family kinases
FLT3 signaling through SRC family kinases
FLT3 signaling by CBL mutants
Drugs
Sorafenib
Sunitinib
XL999
Tandutinib
Linifanib
Lestaurtinib
Midostaurin
Ponatinib
Nintedanib
Pacritinib
Tivozanib
Fostamatinib
Gilteritinib
Brigatinib
Fedratinib
Amuvatinib
Quizartinib
Pexidartinib
Pralsetinib
Diseases
Acute myeloid leukemia (AML)
GWAS
Periodontitis (Mean PAL) (
24024966
)
Triglyceride levels (
32203549
)
Apolipoprotein A1 levels (
32203549
)
Autoimmune thyroid disease (
32581359
)
Basophil count (
32888494
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
HDL cholesterol levels (
32203549
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Monocyte count (
29403010
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Pancreatic cancer (
25086665
)
Plateletcrit (
32888494
)
Psoriasis (
25854761
)
Rapid automised naming of digits (
30741946
)
Serum total protein levels (
29403010
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Tourette syndrome (
30818990
)
White blood cell count (
27863252
32888494
)
White blood cell count (monocyte) (
28158719
)
Interacting Genes
4 interacting genes:
FLT3
KLHL20
NRL
OGT
18 interacting genes:
CBL
CBLB
CTNNB1
ERBB2
FIZ1
FLT3LG
GRB2
IKBKG
INPP5D
NCK1
PTPN11
PTPN12
PTPN6
SH3BP2
SLA
SOCS1
SRC
UBE2L6
Entrez ID
84922
2322
HPRD ID
07870
00635
Ensembl ID
ENSG00000179943
ENSG00000122025
Uniprot IDs
Q96SL8
P36888
PDB IDs
1RJB
3QS7
3QS9
4RT7
4XUF
5X02
6IL3
6JQR
7QDP
7ZV9
8XB1
Enriched GO Terms of Interacting Partners
?
Protein N-acetylglucosaminyltransferase Complex
Negative Regulation Of Non-canonical Inflammasome Complex Assembly
Type II Interferon Binding
Vascular Endothelial Growth Factor Receptor Activity
Common Myeloid Progenitor Cell Proliferation
Cell Development
Pro-B Cell Differentiation
Myeloid Progenitor Cell Differentiation
Phosphatidylinositol 3-kinase Activator Activity
Hemopoiesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose
Non-canonical Inflammasome Complex Assembly
Positive Regulation Of Transcription By Glucose
Carbon Catabolite Regulation Of Transcription
Regulation Of Transcription From RNA Polymerase II Promoter By Glucose
Protein O-acetylglucosaminyltransferase Activity
Protein K33-linked Ubiquitination
Retinal Rod Cell Development
Regulation Of Transcription By Glucose
Regulation Of Programmed Cell Death
Leucine Zipper Domain Binding
NSL Complex
Lymphoid Progenitor Cell Differentiation
Phosphotyrosine Residue Binding
Receptor Tyrosine Kinase Binding
Regulation Of Lymphocyte Activation
Ephrin Receptor Binding
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Activation
ERBB Signaling Pathway
Negative Regulation Of Immune System Process
Regulation Of Mononuclear Cell Proliferation
Regulation Of T Cell Activation
Regulation Of Leukocyte Proliferation
Cellular Response To Growth Factor Stimulus
SH3 Domain Binding
Response To Growth Factor
Negative Regulation Of Leukocyte Activation
Regulation Of MAPK Cascade
Positive Regulation Of Lymphocyte Activation
Negative Regulation Of Cell Activation
Regulation Of Cell-cell Adhesion
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Leukocyte Cell-cell Adhesion
Leukocyte Activation
Positive Regulation Of Cell Activation
Immune System Process
Antigen Receptor-mediated Signaling Pathway
Negative Regulation Of Neutrophil Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Lymphocyte Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Cell Activation
Regulation Of T Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Neutrophil Activation
T Cell Receptor Signaling Pathway
T Cell Costimulation
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Neutrophil Activation Involved In Immune Response
Immune Response-activating Signaling Pathway
Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Regulation Of Cell Adhesion
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Tagcloud (Intersection)
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