FIZ1 and FLT3

Number of citations of the paper that reports this interaction (PMID 10409713)
3

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FIZ1	FLT3
Gene Name		FLT3-interacting zinc finger 1	fms-related tyrosine kinase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Endoplasmic Reticulum Lumen Cytosol Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein Complex
	Molecular Function	Nucleic Acid Binding Receptor Tyrosine Kinase Binding Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Complex Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Pro-T Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Organ Regeneration Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of B Cell Differentiation Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation
Pathways
Drugs			Sorafenib Sunitinib Ponatinib
Diseases
GWAS
Protein-Protein Interactions		2 interactors: FLT3 NRL	14 interactors: CBL CBLB FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN12 PTPN6 SH3BP2 SLA SOCS1 UBE2L6
Entrez ID		84922	2322
HPRD ID		07870	00635
Ensembl ID		ENSG00000179943	ENSG00000122025
Uniprot IDs		Q96SL8	P36888
PDB IDs			1RJB 3QS7 3QS9
Enriched GO Terms of Interacting Partners?		Pro-T Cell Differentiation Positive Regulation Of Rhodopsin Gene Expression Common Myeloid Progenitor Cell Proliferation Regulation Of Rhodopsin Gene Expression Pro-B Cell Differentiation Negative Regulation Of B Cell Differentiation Myeloid Progenitor Cell Differentiation Retinal Rod Cell Development Lymphoid Progenitor Cell Differentiation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of B Cell Differentiation Eye Photoreceptor Cell Development Negative Regulation Of B Cell Activation Dendritic Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Photoreceptor Cell Development Eye Photoreceptor Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Regulation Of Lipid Kinase Activity Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Organ Regeneration Leukocyte Homeostasis Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of JAK-STAT Cascade	Negative Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Negative Regulation Of Signaling Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Cell Activation Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Immune Response Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Defense Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Dephosphorylation Regulation Of B Cell Differentiation
Tagcloud ?		abrogates advantage balance balancing concurrent dbf2 demonstrating finger flt3 govern governed hacat homeostasis igf1 igfbp3 immortalized interactome keratinocytes mapped mediating multitude ndr neutralization partners player secretome silac transducer utilizing	action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated
Tagcloud (Difference) ?		abrogates advantage balance balancing concurrent dbf2 demonstrating finger govern governed hacat homeostasis igf1 igfbp3 immortalized interactome keratinocytes mapped mediating multitude ndr neutralization partners player secretome silac transducer utilizing	action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated
Tagcloud (Intersection) ?		flt3