PLXNC1 and SEMA7A

Number of citations of the paper that reports this interaction (PubMedID 10520995)
0

Data Source:
HPRD (in vitro, in vivo)

		PLXNC1	SEMA7A
Description		plexin C1	semaphorin 7A (JohnMiltonHagen blood group)
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Side Of Membrane Presynapse GABA-ergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Semaphorin Receptor Activity	Integrin Binding Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Regulation Of Cell Migration Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Regulation Of Synapse Pruning	Osteoblast Differentiation Neural Crest Cell Migration Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Nervous System Development Axon Guidance Olfactory Lobe Development Cell Differentiation Positive Regulation Of Cell Migration Neuron Projection Development Positive Regulation Of Axon Extension Axon Extension Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Regulation Of Synapse Maturation
Pathways		Other semaphorin interactions	Other semaphorin interactions Other semaphorin interactions
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31959851 32296059 34103634) Blood protein levels ( 30072576) Diastolic blood pressure ( 30578418) Femur bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602) Multiple sclerosis ( 31604244) Pulse pressure ( 30578418) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)	Airflow obstruction ( 22837378) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Craniofacial microsomia ( 26853712) HDL cholesterol levels ( 32203549) Hypertension ( 31879980)
Interacting Genes		1 interacting genes: SEMA7A	1 interacting genes: PLXNC1
Entrez ID		10154	8482
HPRD ID		05036	07081
Ensembl ID		ENSG00000136040	ENSG00000138623
Uniprot IDs		O60486	B3KMH6 F5GYX3 O75326
PDB IDs		3KUZ 3NVN 3NVQ 6VXK	3NVQ
Enriched GO Terms of Interacting Partners?		Olfactory Lobe Development	Regulation Of Cell Motility Microtubule Anchoring At Centrosome Positive Regulation Of Cellular Component Organization Cytokine-mediated Signaling Pathway Protein Localization To Non-motile Cilium BBSome Regulation Of Locomotion Photoreceptor Cell Outer Segment Organization Retinal Rod Cell Development Negative Regulation Of Appetite Positive Regulation Of Organelle Assembly Protein Localization To Photoreceptor Outer Segment Positive Regulation Of Multicellular Organismal Process Striatum Development Fat Pad Development Positive Regulation Of Developmental Process Regulation Of Protein-containing Complex Assembly Erythrocyte Homeostasis Leptin-mediated Signaling Pathway Sensory Processing Dynactin Binding Regulation Of Non-motile Cilium Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Adult Behavior Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Organelle Assembly Cholinergic Synapse Acetylcholine-gated Monoatomic Cation-selective Channel Activity Behavioral Response To Nicotine Acetylcholine Receptor Activity Dopaminergic Synapse Acetylcholine-gated Channel Complex Neurotransmitter Receptor Complex Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Positive Regulation Of Interleukin-23 Production Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Epithelial Fluid Transport Regulation Of Interleukin-23 Production Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Neutrophil Differentiation Response To Silicon Dioxide Histamine Transport Histamine Secretion Semaphorin Receptor Complex Regulation Of Synapse Pruning
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