MGARP and DAPP1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		MGARP	DAPP1
Description		mitochondria localized glutamic acid rich protein	dual adaptor of phosphotyrosine and 3-phosphoinositides 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane Axon Cytoplasm	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Protein Targeting To Mitochondrion Anterograde Axonal Transport Retrograde Axonal Transport Regulation Of Mitochondrion Organization Axonal Transport Of Mitochondrion Cerebral Cortex Development Axon Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Cellular Response To Gonadotropin-releasing Hormone Negative Regulation Of Dendrite Development	Protein Dephosphorylation Signal Transduction
Pathways			Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Central corneal thickness ( 32528159)	Red cell distribution width ( 32888494) Stroke ( 32693751)
Interacting Genes		3 interacting genes: DAPP1 EGFR TRIM54	23 interacting genes: BTK CNDP2 ERBB3 FAIM FCHSD2 FXN GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1
Entrez ID		84709	27071
HPRD ID		17805	05773
Ensembl ID		ENSG00000137463	ENSG00000070190
Uniprot IDs		Q8TDB4	J3KNB3 Q9UN19
PDB IDs			1FAO 1FB8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Binding	Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Phospholipase Activator Activity Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phospholipase Binding Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Response To Lipid Immune Response-activating Signaling Pathway Membrane Raft Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Histamine Secretion By Mast Cell Positive Regulation Of Immune Response Protein Autophosphorylation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of MAPK Cascade Cellular Response To Lipid Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Developmental Process T Cell Costimulation Positive Regulation Of Immune System Process Histamine Secretion Positive Regulation Of Epithelial Cell Migration Protein Kinase Activity Positive Regulation Of Innate Immune Response Signaling Receptor Activator Activity Release Of Sequestered Calcium Ion Into Cytosol Histamine Transport Negative Regulation Of Sequestering Of Calcium Ion
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