KIAA1804 and MAP3K10

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		KIAA1804	MAP3K10
Gene Name		mixed lineage kinase 4	mitogen-activated protein kinase kinase kinase 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Cytoplasm
	Molecular Function	MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Protein Homodimerization Activity	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS		Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		1 interactors: MAP3K10	30 interactors: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS HGS HTT KIAA1804 KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 TUBB YWHAE
Entrez ID		84451	4294
HPRD ID		10087	02533
Ensembl ID		ENSG00000143674	ENSG00000130758
Uniprot IDs		Q5TCX8	Q02779
PDB IDs			2RF0
Enriched GO Terms of Interacting Partners?		Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-threonine Phosphorylation Activation Of MAPKK Activity Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity JNK Cascade Smoothened Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Protein Autophosphorylation Positive Regulation Of MAP Kinase Activity MAPK Cascade	Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component Signal Transduction Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signaling Regulation Of Signaling Cell Communication Neurogenesis Cell Differentiation Regulation Of JNK Cascade Generation Of Neurons Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of MAPK Cascade Organelle Organization Cellular Localization Cellular Response To Stimulus Neuron Differentiation Response To Stimulus Regulation Of Apoptotic Process Developmental Process Organelle Transport Along Microtubule Regulation Of Phosphorus Metabolic Process MAPK Cascade Response To Stress Intracellular Transport Regulation Of Cell Death Protein Localization Nervous System Development Cytoskeleton-dependent Intracellular Transport Regulation Of Body Fluid Levels Positive Regulation Of Intracellular Signal Transduction Plus-end-directed Vesicle Transport Along Microtubule Wound Healing Regulation Of Catalytic Activity Signal Transduction By Phosphorylation Membrane Organization Transport JNK Cascade Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Microtubule-based Movement Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule Response To Wounding
Tagcloud ?		3p 3q abcc5 agtr1 amplifications bcl6 beadarray beadarraytrade cdkn2a cdkn2b coincidently csf1 ctnnb1 dnas dvl3 esophageal fancd2 ffpe fgf12 hapmap il2 irf7 map3k9 mlf1 ntrk2 pms2 prkar1a tnfsf10 tnk2	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		3p 3q abcc5 agtr1 amplifications bcl6 beadarray beadarraytrade cdkn2a cdkn2b coincidently csf1 ctnnb1 dnas dvl3 esophageal fancd2 ffpe fgf12 hapmap il2 irf7 map3k9 mlf1 ntrk2 pms2 prkar1a tnfsf10 tnk2	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?