TMEM101 and MAP4K1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TMEM101	MAP4K1
Description		transmembrane protein 101	mitogen-activated protein kinase kinase kinase kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Cytoplasm Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Canonical NF-kappaB Signal Transduction	Protein Phosphorylation JNK Cascade Cell Population Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways
Drugs			Fostamatinib
Diseases
GWAS			Diisocyanate-induced asthma ( 25918132)
Interacting Genes		21 interacting genes: ACKR5 ARLN BNIP3 CCR4 DRD2 GIMAP1 MAP4K1 NDUFA3 NINJ2 NPSR1 PDZK1IP1 PKMYT1 STRIT1 STX10 SYNJ2BP TMEM243 TMEM65 TMIE VAMP1 VAMP2 VAPB	24 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 PPP2CA SHC1 STRN4 SYK TMEM101
Entrez ID		84336	11184
HPRD ID		14623	03583
Ensembl ID		ENSG00000091947	ENSG00000104814
Uniprot IDs		B4DFS4 Q96IK0	Q92918
PDB IDs			6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0 7KAC 7L24 7L25 7L26 7M0K 7M0L 7M0M 7R9L 7R9N 7R9P 7R9T 7SIU 8CDW 8CIJ 8EEC 8FH4 8FJZ 8FKO 8PAR 8PAS 8PAU 8XN7 9BI8 9BIK 9BJ1 9CZT 9CZU 9CZW 9CZX 9D00 9H8D 9H8E 9H8F
Enriched GO Terms of Interacting Partners?		Membrane Synaptic Vesicle Membrane SNARE Complex SNAP Receptor Activity Syntaxin Binding Mitochondrial Outer Membrane SNARE Complex Assembly Interneuron Migration Vesicle Fusion Organelle Membrane Fusion Vesicle Organization Organelle Fusion	Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Ephrin Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Signal Transduction Positive Regulation Of Immune Response Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Immune System Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Receptor Tyrosine Kinase Binding Lymphocyte Homeostasis Leukocyte Activation Regulation Of T Cell Activation Leukocyte Homeostasis Lymphocyte Activation Cell Activation Positive Regulation Of Cell Population Proliferation Homeostasis Of Number Of Cells Cytosol Positive Regulation Of Cell Adhesion SH2 Domain Binding Regulation Of Lymphocyte Activation Protein Domain Specific Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway
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