ZNF414 and CFP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF414	CFP
Description		zinc finger protein 414	complement factor properdin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Specific Granule Lumen Cytoplasmic Side Of Golgi Membrane Tertiary Granule Lumen
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Complement Activation, Alternative Pathway Positive Regulation Of Immune Response Protein Stabilization Positive Regulation Of Opsonization
Pathways			Alternative complement activation Activation of C3 and C5 Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins Neutrophil degranulation Regulation of Complement cascade
Drugs
Diseases			Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS
Interacting Genes		55 interacting genes: ADAMTSL4 CALCOCO2 CARD10 CFP CNFN CYSRT1 FBLN2 GOLGA2 GOLGA6L9 HOMER3 ITIH6 KANK2 KRT31 KRT34 KRT36 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP13-3 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP3-1 KRTAP4-12 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-3 MDFI MGAT5B MKRN3 MTUS2 NBPF19 NOTCH2NLA PDE4DIP PICK1 POU2AF1 PPP1R16A RBCK1 RBM11 RNF125 SH2B2 SORBS3 SPRED2 TERF2IP TEX11 TLE5 TRIM10 TRIM27 TRIM42 WWOX ZMYND12	33 interacting genes: BANF2 C3 CFAP206 CFB CYSRT1 FHL5 FKBP6 GEMIN4 GNE HEXIM2 HOXA1 KCTD9 KLHL38 KRTAP11-1 KRTAP12-2 KRTAP3-1 KRTAP6-2 LCE1A LONRF1 MID2 MTOR NEK6 NOXA1 PRKAB2 RECK SMARCC1 SPAG8 STK16 TRIP13 TXN VENTX ZNF330 ZNF414
Entrez ID		84330	5199
HPRD ID		17511	02308
Ensembl ID		ENSG00000133250	ENSG00000126759
Uniprot IDs		Q96IQ9	A0A0S2Z4I5 P27918
PDB IDs			1W0R 1W0S 6RUR 6RUS 6RUV 6RV6 6S08 6S0A 6S0B 6SEJ 7B26 7NOZ 8Q6R
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Keratinization Protein Binding Identical Protein Binding Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process
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