MRPL45 and PLEKHA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MRPL45	PLEKHA3
Description		mitochondrial ribosomal protein L45	pleckstrin homology domain containing A3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Golgi Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane Recycling Endosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding Lipid Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Mitochondrial Translation	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi
Pathways			Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Ovarian cancer ( 23535730)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CAVIN1 EMD PFDN5 PLEKHA3 PRKN TRIM23	8 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B RNMT SH2B2 TCL1B
Entrez ID		84311	65977
HPRD ID		14764	09688
Ensembl ID		ENSG00000278845	ENSG00000116095
Uniprot IDs		A0A087WU62 A0A087X2D5 B4DEF8	Q9HB20
PDB IDs			2KCJ 2MDX 3RCP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway TMEM240-body Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly Termination Of RNA Polymerase I Transcription RRNA Primary Transcript Binding Positive Regulation Of Intracellular Transport Golgi Membrane Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Endoplasmic Reticulum Negative Regulation Of Supramolecular Fiber Organization Positive Regulation Of Autophagy Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Regulation Of Synaptic Vesicle Transport Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Protein-containing Complex Negative Regulation Of Neurotransmitter Secretion Regulation Of Retrograde Transport, Endosome To Golgi
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