NUDT16L1 and TRAF7

		NUDT16L1	TRAF7
Description		nudix hydrolase 16 like 1	TNF receptor associated factor 7
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GO Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Nucleus Cytoplasm Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding Protein Homodimerization Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Phosphodiesterase Decapping Endonuclease Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MRNA Catabolic Process Sno(s)RNA Catabolic Process Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein K29-linked Ubiquitination Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Diastolic blood pressure ( 30578418) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		52 interacting genes: APP CABP2 CEBPA ERBB2 FBXO7 HNRNPF HNRNPH1 IKZF3 INCA1 KRT31 LRRK1 METTL17 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR141 MIR145 MIR18B MIR200C MIR21 MIR25 MIR31 MIR34A MIR34B MIR363 MIR451A MIR7-3 MIR9-1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4L NEK6 NTAQ1 PNMA1 RECK SMARCD1 TRAF2 TRAF4 TRIM68 ZRANB1	11 interacting genes: CYLD MAP3K3 OGT RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6
Entrez ID		84309	84231
HPRD ID		15309	06977
Ensembl ID		ENSG00000168101	ENSG00000131653
Uniprot IDs		B2RD96 K7ENA3 Q9BRJ7 W4VSQ8	B3KQY7 Q6Q0C0
PDB IDs		3KVH 5ZCJ 6CO1 6D0L 8U3S	8IMS
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Biosynthetic Process RNA Destabilization Negative Regulation Of Metabolic Process Positive Regulation Of MRNA Catabolic Process Extracellular Vesicle Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Angiogenesis Regulation Of Vasculature Development Extracellular Space Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Nucleotide Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Ubiquitination Ubiquitin-like Protein Transferase Activity ATP Binding Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Regulation Of Necroptotic Process Positive Regulation Of Protein Modification Process Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Regulation Of DNA-binding Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of P38MAPK Cascade Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Positive Regulation Of Protein Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Gene Expression Involved In Extracellular Matrix Organization Cytosol Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction TORC1 Signaling Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Autoubiquitination
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