EIF1AD and MREG

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EIF1AD	MREG
Description		eukaryotic translation initiation factor 1A domain containing	melanoregulin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Lysosome Lysosomal Membrane Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Late Endosome Membrane Protein-containing Complex Melanosome Membrane Melanosome
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	Protein Binding Lipid Binding Phosphatidylinositol Binding
	Biological Process	Translational Initiation	Melanocyte Differentiation Melanosome Localization Melanosome Transport Pigmentation Developmental Pigmentation Minus-end-directed Organelle Transport Along Microtubule Phagosome Maturation
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Serum uric acid levels ( 32271837)	Blood trace element (Se levels) ( 23720494) Coronary artery disease ( 32469254) Macular thickness ( 30535121) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		34 interacting genes: AP2M1 BEND7 CCDC106 CEP55 CEP76 DPPA2 DRC4 GCSAML GLYR1 GTF2H4 LNX1 MEOX2 MID2 MREG PAX6 PBX4 PICK1 PINX1 RASSF10 RBAK RBM48 SDCBP SDCBP2 STAT1 STX11 TBC1D5 TEPSIN TLE5 TNNI1 ZBTB14 ZBTB8A ZNF280A ZNF521 ZNF558	6 interacting genes: CFTR CPSF7 EIF1AD HNRNPLL MAP1LC3A PUF60
Entrez ID		84285	55686
HPRD ID		14411	07645
Ensembl ID		ENSG00000175376	ENSG00000118242
Uniprot IDs		Q8N9N8	Q8N565
PDB IDs		2DGY 6ZXF 6ZXG 6ZXH
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis AP-2 Adaptor Complex Protein Binding	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding MRNA Processing RNA Binding Nucleic Acid Binding MRNA Metabolic Process Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization MRNA Alternative Polyadenylation Cellular Response To Oxygen-glucose Deprivation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of RNA Splicing RNA Processing MRNA Cleavage Factor Complex Response To Iron(II) Ion Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Binding Cellular Response To Nitrogen Starvation Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Response To Oxygen-glucose Deprivation Autolysosome Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Phosphatidylethanolamine Binding Cellular Response To Forskolin Protein Heterotetramerization Response To Forskolin MRNA Cleavage And Polyadenylation Specificity Factor Complex Chloride Transmembrane Transporter Activity Sperm Capacitation Response To Lead Ion Ribonucleoprotein Complex
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