MREG

Description		melanoregulin
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Late Endosome Membrane Protein-containing Complex Melanosome Membrane Melanosome
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol Binding
	Biological Process	Melanocyte Differentiation Melanosome Localization Melanosome Transport Pigmentation Developmental Pigmentation Minus-end-directed Organelle Transport Along Microtubule Phagosome Maturation
Pathways
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Coronary artery disease ( 32469254) Macular thickness ( 30535121) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		6 interacting genes: CFTR CPSF7 EIF1AD HNRNPLL MAP1LC3A PUF60
Entrez ID		55686
HPRD ID		07645
Ensembl ID		ENSG00000118242
Uniprot IDs		Q8N565
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding MRNA Processing RNA Binding Nucleic Acid Binding MRNA Metabolic Process Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization MRNA Alternative Polyadenylation Cellular Response To Oxygen-glucose Deprivation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of RNA Splicing RNA Processing MRNA Cleavage Factor Complex Response To Iron(II) Ion Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Binding Cellular Response To Nitrogen Starvation Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Response To Oxygen-glucose Deprivation Autolysosome Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Phosphatidylethanolamine Binding Cellular Response To Forskolin Protein Heterotetramerization Response To Forskolin MRNA Cleavage And Polyadenylation Specificity Factor Complex Chloride Transmembrane Transporter Activity Sperm Capacitation Response To Lead Ion Ribonucleoprotein Complex
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