RNF135 and RARRES3

Number of citations of the paper that reports this interaction (PMID 19017631)
43

Data Source:
BioGRID (enzymatic study)

		RNF135	RARRES3
Gene Name		ring finger protein 135	retinoic acid receptor responder (tazarotene induced) 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ribonucleoprotein Complex Binding	Phospholipase A2 Activity Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Regulation Of Innate Immune Response	Phospholipid Metabolic Process Negative Regulation Of Cell Proliferation Lipid Catabolic Process
Pathways		TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		5 interactors: CTNNAL1 DDX58 GOLGA2 RARRES3 UBE2D2	6 interactors: HRAS RNF135 SGTA TGM1 TRIM25 UBC
Entrez ID		84282	5920
HPRD ID		11506	05479
Ensembl ID		ENSG00000181481	ENSG00000133321
Uniprot IDs		B3KV69 Q8IUD6	Q9UL19
PDB IDs			2LKT
Enriched GO Terms of Interacting Partners?		Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response RIG-I Signaling Pathway Regulation Of Type III Interferon Production Detection Of Virus Regulation Of Innate Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Cellular Response To Virus Positive Regulation Of Defense Response To Virus By Host Immune Response-regulating Signaling Pathway Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Defense Response To Virus By Host Positive Regulation Of Immune Response	Negative Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Negative Regulation Of Cytokine Production Innate Immune Response Immune Response Defense Response Positive Regulation Of Type I Interferon Production Regulation Of Cytokine Production Viral Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Envelope Organization Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Rac Protein Signal Transduction Negative Regulation Of Mitotic Cell Cycle Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Cycle Checkpoint Positive Regulation Of MiRNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Ruffle Assembly Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of MiRNA Metabolic Process Viral Protein Processing Regulation Of Immune System Process Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Rho GTPase Activity
Tagcloud ?		asians blacks brd3 challenges childhood crlf2 cured differ differentially disparities distributed erbb2 erbb3 ethnic exist follows hispanics implicated lymphoblastic networks pdgf pediatric persist phf6 pi3 populations racial united whites	acyl acylation advance catenin cdd decision deregulation doi embryonic emerged fate indicates insight link lipoprotein mesenchymal modulates modulating november online pivotal publication serves tethers thioesterase transition tumorigenesis whereby wnt
Tagcloud (Difference) ?		asians blacks brd3 challenges childhood crlf2 cured differ differentially disparities distributed erbb2 erbb3 ethnic exist follows hispanics implicated lymphoblastic networks pdgf pediatric persist phf6 pi3 populations racial united whites	acyl acylation advance catenin cdd decision deregulation doi embryonic emerged fate indicates insight link lipoprotein mesenchymal modulates modulating november online pivotal publication serves tethers thioesterase transition tumorigenesis whereby wnt
Tagcloud (Intersection) ?