TSSK6 and LYL1

		TSSK6	LYL1
Description		testis specific serine kinase 6	LYL1 basic helix-loop-helix family member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Cilium Motile Cilium Sperm Flagellum Cell Projection Axonemal Microtubule Doublet Inner Sheath	Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity
	Biological Process	Protein Phosphorylation Spermatogenesis Spermatid Development Cell Differentiation Flagellated Sperm Motility Sperm DNA Condensation	Blood Vessel Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of DNA-templated Transcription Definitive Hemopoiesis
Pathways			NGF-stimulated transcription
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Percent liver fat ( 34128465) Refractive error ( 32231278) Schizophrenia ( 23974872 25056061 29483656)	Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Household income ( 31844048) Household income (MTAG) ( 31844048) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: APP H2AC20 H2AX H3C1 HSP90AB1 HSPA1A HSPA8 MBP	8 interacting genes: DRG1 LMO1 LMO2 NFKB1 NFKBIA RHOU TCF3 TCF4
Entrez ID		83983	4066
HPRD ID		15441	01046
Ensembl ID		ENSG00000178093	ENSG00000104903
Uniprot IDs		A0A024R7Q5 Q9BXA6	P12980
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Import Extracellular Exosome ATP-dependent Protein Folding Chaperone C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Protein Folding Chaperone Heat Shock Protein Binding G Protein-coupled Receptor Binding Protein-containing Complex Organization Structural Constituent Of Chromatin Response To Unfolded Protein Epigenetic Regulation Of Gene Expression Cadherin Binding Unfolded Protein Binding Cellular Component Assembly Protein Heterodimerization Activity Nucleosome Ficolin-1-rich Granule Lumen Receptor Ligand Activity Chaperone-mediated Protein Complex Assembly Regulation Of Macromolecule Metabolic Process Enzyme Binding Regulation Of Proteolysis Protein-containing Complex Protein-containing Complex Assembly Disordered Domain Specific Binding MHC Class II Protein Complex Binding Protein Refolding Protein Folding Chaperone Complex COP9 Signalosome Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Proteolysis Positive Regulation Of Nitric Oxide Metabolic Process Protein Folding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleus Cellular Response To Heat Chaperone-mediated Autophagy Translocation Complex Disassembly Positive Regulation Of Metalloendopeptidase Activity Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Chromatin Remodeling Acetylcholine Receptor Activator Activity Positive Regulation Of Metabolic Process	Positive Regulation Of Transcription By RNA Polymerase II I-kappaB/NF-kappaB Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II BHLH Transcription Factor Binding Response To Muscle Stretch Positive Regulation Of Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Non-canonical NF-kappaB Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Lipid Storage Protein Sequestering Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To DsRNA Positive Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding B Cell Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction E-box Binding Tumor Necrosis Factor-mediated Signaling Pathway Histone H4K8ac Reader Activity Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Cholesterol Transport Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Immune System Process Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of DNA-templated Transcription Initiation NF-kappaB P50/p65 Complex Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Regulation Of Developmental Process Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Axonemal Microtubule Doublet Inner Sheath Positive Regulation Of Neuron Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process
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