GRWD1 and RPL11

Number of citations of the paper that reports this interaction (PubMedID 31903119)
55

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		GRWD1	RPL11
Description		glutamate rich WD repeat containing 1	ribosomal protein L11
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding DNA Replication Origin Binding RNA Binding Protein Binding Histone Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding RRNA Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	DNA Replication Nucleosome Assembly Nucleosome Disassembly Ribosome Biogenesis	Ribosomal Large Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Protein Targeting Positive Regulation Of Gene Expression Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Ribosomal Large Subunit Biogenesis Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases			Diamond-Blackfan anemia (DBA)
GWAS
Interacting Genes		10 interacting genes: CDC42 CEBPA ESR1 OGT PCAT1 RPL11 RPL23 SLC25A21-AS1 TP53 USP7	25 interacting genes: APP ARFGAP1 BLMH CAMK2B CDKN2A DVL3 GRWD1 HP HSPB2 IGF1R IP6K1 KRT40 KRTAP10-7 LIG4 MDM2 OGT OSBPL3 PAIP2 PCAT1 PML SENP1 STAT3 TIGAR TP73 UBE2I
Entrez ID		83743	6135
HPRD ID		11013	10364
Ensembl ID		ENSG00000105447	ENSG00000142676
Uniprot IDs		Q9BQ67	P62913 Q5VVD0
PDB IDs			4UG0 4V6X 4XXB 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8BGU 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Negative Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Actinomycin D Negative Regulation Of Catabolic Process Response To Actinomycin D Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transcription Coactivator Binding Regulation Of G1 To G0 Transition Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Stabilization Rhythmic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Negative Regulation Of Ubiquitin Protein Ligase Activity Cellular Response To Antibiotic Protein Localization To Organelle Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin Ligase Inhibitor Activity Regulation Of Glucose Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Catabolic Process Cytoplasmic Translation Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Stem Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Response To Nutrient Levels Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Nucleus 14-3-3 Protein Binding Intracellular Protein Localization Regulation Of Protein Ubiquitination Positive Regulation Of Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Response To Antibiotic Regulation Of Catalytic Activity Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Metabolic Process	SUMO Transferase Activity Protein Sumoylation Regulation Of Glycolytic Process Negative Regulation Of Catabolic Process Response To Gamma Radiation Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of ATP Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Amyloid Fibril Formation Regulation Of Cellular Response To Stress Positive Regulation Of Developmental Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cytosol Regulation Of Proteolysis Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Programmed Cell Death Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Hydrogen Peroxide Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Generation Of Precursor Metabolites And Energy Oncogene-induced Cell Senescence Positive Regulation Of Apoptotic Process Involved In Morphogenesis Negative Regulation Of Translational Initiation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Involved In Development Response To Ionizing Radiation Response To Xenobiotic Stimulus Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of Cellular Component Organization Somatic Stem Cell Population Maintenance MDM2/MDM4 Family Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Protein Localization To Nucleus P53 Binding Autophagy Of Mitochondrion Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Carbohydrate Homeostasis Glucose Homeostasis
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