H2AB3 and H2BC13

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		H2AB3	H2BC13
Name		H2A.B variant histone 3	H2B clustered histone 13
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleosome Euchromatin Nucleus Chromosome	Nucleosome Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Nucleosome Assembly MRNA Processing Heterochromatin Formation	Nucleosome Assembly
Pathways		None	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: RIPK1
Interacting Genes		3 interacting genes: H2BC13 H2BC15 MESD	5 interacting genes: AP2M1 CDC42 H2AB2 H2AB3 VHL
Entrez ID		83740	8340
HPRD ID		06581	11898
Ensembl ID		ENSG00000277745	ENSG00000185130
Uniprot IDs		P0C5Z0	Q99880
PDB IDs		6A7U 6M4G 6M4H	Not available
GO Terms Enriched among Interactors		Nucleosome Nucleosome Assembly Nucleosome Organization Structural Constituent Of Chromatin Protein-DNA Complex Assembly Protein Heterodimerization Activity Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Chromatin Remodeling Chromosome Low-density Lipoprotein Particle Receptor Binding Protein Localization To Cell Surface Chromatin Organization Mesoderm Development Protein Folding Chaperone	Amyloid Fibril Formation Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Storage Vacuole Cellular Component Assembly Supramolecular Fiber Organization Protein-containing Complex Organization Protein-containing Complex Assembly Positive Regulation Of Interleukin-6-mediated Signaling Pathway Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process Nucleosome Heterochromatin Formation Nucleosome Assembly Euchromatin Nucleosome Organization Structural Constituent Of Chromatin Positive Regulation Of Endocytosis Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Signal Sequence Binding Negative Regulation Of Gene Expression, Epigenetic Extrinsic Component Of Presynaptic Endocytic Zone Membrane Positive Regulation Of MiRNA Processing Peptidyl-serine Autophosphorylation Protein-DNA Complex Assembly Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Postsynapse Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Transcription Elongation Factor Activity Ripoptosome Death-inducing Signaling Complex Positive Regulation Of Necroptotic Process Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis JUN Kinase Kinase Kinase Activity Necroptotic Signaling Pathway Leading Edge Membrane Thioesterase Binding Neuron Fate Determination Golgi Transport Complex Positive Regulation Of Programmed Necrotic Cell Death Epigenetic Regulation Of Gene Expression Endothelin Receptor Signaling Pathway