KLRC4 and MICB

Number of citations of the paper that reports this interaction (PubMedID 12133964)
0

Data Source:
HPRD (in vitro)

		KLRC4	MICB
Description		killer cell lectin like receptor C4	MHC class I polypeptide-related sequence B
Image		No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity	Natural Killer Cell Lectin-like Receptor Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Adaptive Immune Response Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Response To Oxidative Stress Response To Heat Negative Regulation Of Defense Response Killing Of Cells Of Another Organism Response To Retinoic Acid Gamma-delta T Cell Activation Negative Regulation Of Defense Response To Virus By Host Regulation Of Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Behcet's disease ( 23291587) Psoriasis ( 28537254)	A body shape index ( 34021172) AIDS progression ( 19115949) Alcohol use disorder ( 30940813) Allergic sensitization ( 23817571) Apolipoprotein B levels ( 32203549) Arterial stiffness index ( 31235810) Asthma ( 29273806 31619474) Asthma (childhood onset) ( 29273806 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Behcet's disease ( 23001997) Cervical cancer ( 28806749) Cold sores ( 28928442) Coronary artery disease ( 33020668) Crohn's disease ( 23128233) Cutaneous lupus erythematosus ( 25827949) Dengue shock syndrome ( 22001756) Fasting insulin ( 34059833) Handedness (non-right-handed vs right-handed) ( 31504236) Hip circumference adjusted for BMI ( 34021172) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 28067908) Kawasaki disease ( 33692975) Malaria ( 31844061) Metabolic syndrome ( 22399527) Midgestational circulating levels of PBDEs ( 28235828) Monocyte count ( 32888494 27863252) Mononucleosis ( 28928442) Myositis ( 26291516) Oral cavity cancer ( 27749845) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Pneumonia ( 28928442) Psychosis (atypical) ( 24132900) Pulmonary function ( 21946350) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		4 interacting genes: MICB RAE1 TYROBP ULBP1	2 interacting genes: KLRC4 KLRK1
Entrez ID		8302	4277
HPRD ID		16008	03894
Ensembl ID		ENSG00000183542	ENSG00000204516
Uniprot IDs		O43908	A0A0G2JHB5 A0A7D9H7X8 B4DUT9 B7Z8M1 F5H7Q8 Q29980
PDB IDs			1JE6 2WY3
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Lectin-like Receptor Binding Lymphocyte Activation Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Leukocyte Activation Positive Regulation Of Immune Response Cell Activation Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Leukocyte Mediated Immunity Negative Regulation Of Defense Response To Virus By Host Regulation Of Immune Response Positive Regulation Of Immune System Process Cell Killing Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Microglial Cell Activation Involved In Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Positive Regulation Of Immune Effector Process Negative Regulation Of Transforming Growth Factor Beta1 Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery T Cell Activation T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Regulation Of Osteoclast Development External Side Of Plasma Membrane Immune Response-activating Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Immune System Process Immune Effector Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response-regulating Signaling Pathway Activation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Negative Regulation Of Defense Response To Virus Negative Regulation Of B Cell Proliferation Immune System Process Gamma-delta T Cell Activation Macrophage Activation Involved In Immune Response Regulation Of Superoxide Anion Generation Cellular Response To Lectin Positive Regulation Of Superoxide Anion Generation Stimulatory C-type Lectin Receptor Signaling Pathway	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Mediated Immunity Innate Immune Response-activating Signaling Pathway Regulation Of Lymphocyte Mediated Immunity Activation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Negative Regulation Of Lymphocyte Chemotaxis Immune Response-activating Signaling Pathway External Side Of Plasma Membrane Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Defense Response Regulation Of Innate Immune Response MHC Class Ib Receptor Activity Positive Regulation Of Immune Response Negative Regulation Of Lymphocyte Migration Negative Regulation Of GTPase Activity MHC Class I Protein Binding Regulation Of Defense Response Nitric Oxide Biosynthetic Process Negative Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Chemotaxis Regulation Of Immune Response Positive Regulation Of Immune System Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Hydrolase Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Nitric Oxide Metabolic Process Natural Killer Cell Mediated Immunity T Cell Costimulation Negative Regulation Of Chemotaxis Negative Regulation Of Leukocyte Migration Natural Killer Cell Activation Regulation Of Nitric Oxide Biosynthetic Process
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