SERF1A and ELOVL7

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SERF1A	ELOVL7
Name		small EDRK-rich factor 1A	ELOVL fatty acid elongase 7
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Fatty Acid Elongase Activity Transferase Activity
	Biological Process	Nervous System Development Protein Destabilization Amyloid Fibril Formation	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process
Pathways		None	Synthesis of very long-chain fatty acyl-CoAs
GWAS		No GWAS studies recorded	Age at first sexual intercourse ( 34211149 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area ( 32963231 ) Cortical surface area (MOSTest) ( 32665545 ) Household income ( 31844048 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Mean platelet volume ( 32888494 27863252 ) Multiple system atrophy ( 27629089 ) Parkinson's disease ( 32201043 28892059 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Refractive error ( 32231278 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Subcortical volume (MOSTest) ( 32665545 ) Working memory ( 31598132 )
Interacting Genes		15 interacting genes: ABHD16A APP AQP6 CERS4 CRB3 ELOVL4 ELOVL7 GPR152 LRRK2 PIK3R3 REEP4 RNASEK TIMMDC1 TMEM14B TMX2	12 interacting genes: ADGRE2 DTNBP1 EMP3 LRCH4 RTP2 SERF1A SERF1B SLC41A1 SYNJ2BP TMEM14C UBE2J2 VAMP1
Entrez ID		8293	79993
HPRD ID		04308	18700
Ensembl ID		ENSG00000172058	ENSG00000164181
Uniprot IDs		O75920	A1L3X0 D6RHD0
PDB IDs		Not available	6Y7F
GO Terms Enriched among Interactors		Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Mitochondrial Membrane Membrane Cellular Response To Manganese Ion Fatty Acid Elongation, Saturated Fatty Acid Fatty Acid Derivative Metabolic Process Response To Manganese Ion Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Sphingolipid Biosynthetic Process Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Response To Catecholamine Long-chain Fatty-acyl-CoA Biosynthetic Process Endoplasmic Reticulum Endoplasmic Reticulum Membrane Long-chain Fatty-acyl-CoA Metabolic Process Amide Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Sphingolipid Metabolic Process Regulation Of Lysosomal Lumen PH Very Long-chain Fatty Acid Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Membrane Lipid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Nitrate Transmembrane Transporter Activity Organophosphate Metabolic Process Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Lipid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process Endoplasmic Reticulum Organization Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Lipid Metabolic Process	None