ARID1A and EDEM1

		ARID1A	EDEM1
Description		AT-rich interaction domain 1A	ER degradation enhancing alpha-mannosidase like protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Aggresome Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nucleosome Binding	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Carbohydrate Metabolic Process Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Glycoprotein Metabolic Process ERAD Pathway Protein Targeting To ER Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Positive Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	XBP1(S) activates chaperone genes ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 28869591 30598549) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver volume ( 34128465) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) White matter hyperintensities in ischemic stroke ( 26674333)	Alzheimer's disease ( 33074286) Diverticular disease ( 30177863) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Uterine fibroids ( 28836065)
Interacting Genes		19 interacting genes: ESR1 EWSR1 EZH2 FUS GATA1 HIC1 ITCH KLF1 MLLT1 NCOA1 NEDD4 PGR RARA RARB RARG SMARCA4 TAF15 TP53 TTC3	1 interacting genes: CANX
Entrez ID		8289	9695
HPRD ID		04319	09644
Ensembl ID		ENSG00000117713	ENSG00000134109
Uniprot IDs		O14497	Q92611
PDB IDs		1RYU 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?		Chromatin Nuclear Receptor-mediated Signaling Pathway Regulation Of DNA-templated Transcription Chromatin Binding Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Zinc Ion Binding Transcription Coactivator Binding Nuclear Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Glandular Epithelial Cell Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Growth Plate Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Progesterone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Biosynthetic Process Metal Ion Binding Transcription Regulator Complex Epithelial Cell Development Columnar/cuboidal Epithelial Cell Development Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific MRNA Transcription Nuclear Retinoid X Receptor Binding DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Cartilage Development Involved In Endochondral Bone Morphogenesis Embryonic Organ Development Transcription By RNA Polymerase II	Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Melanosome Membrane Secretion By Cell Protein Folding In Endoplasmic Reticulum Secretion Presynapse Positive Regulation Of Lymphocyte Activation Nucleosome Disassembly BBAF Complex Brahma Complex NBAF Complex Protein-DNA Complex Disassembly Regulation Of Lymphocyte Activation NpBAF Complex Positive Regulation Of Cell Activation Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Negative Regulation Of B Cell Apoptotic Process Protein-macromolecule Adaptor Activity Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Insulin Receptor Binding Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of B Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Fatty Acid Oxidation Response To Endothelin Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cellular Response To Endothelin Pore Complex Regulation Of Synaptic Assembly At Neuromuscular Junction Pore Complex Assembly
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