FXYD6-FXYD2 and APH1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FXYD6-FXYD2	APH1B
Description		FXYD6-FXYD2 readthrough	aph-1B gamma-secretase subunit
Image		No pdb structure
GO Annotations	Cellular Component		Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Membrane Transport Vesicle Gamma-secretase Complex
	Molecular Function		Protein Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process		Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process
Pathways			Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Estimated glomerular filtration rate ( 31152163) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		34 interacting genes: APH1B APOL3 AQP6 AVPR2 BEST1 BNIP3 CERS4 CLDN5 ERGIC3 FAM210B GPR152 GPR37L1 GPRC5D MTIF3 PGRMC2 RNF170 SLC10A1 SLC10A6 SLC16A13 SLC19A3 SLC2A13 SLC34A2 SLC35H1 SLC7A8 SPCS1 TLCD4 TMEM14B TMEM167B TMEM205 TMEM41A TMPPE TMX2 TRHR UNC93A	7 interacting genes: FXYD6-FXYD2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1
Entrez ID		100533181	83464
HPRD ID			06361
Ensembl ID		ENSG00000255245	ENSG00000138613
Uniprot IDs		A0A087WZ82 A0A0A6YYL5	Q8WW43
PDB IDs			8OQY 8OQZ
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Bile Acid:sodium Symporter Activity Symporter Activity Organic Anion Transport Renal Water Transport Carboxylic Acid Transport Organic Acid Transport Protein Binding Organic Hydroxy Compound Transport Endoplasmic Reticulum G Protein-coupled Receptor Activity Bile Acid And Bile Salt Transport	Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Membrane Protein Proteolysis Growth Factor Receptor Binding Synaptic Membrane Notch Signaling Pathway Presynaptic Membrane Synaptic Vesicle Protein Processing Cerebellum Development Azurophil Granule Membrane Protein Maturation Early Endosome Negative Regulation Of Core Promoter Binding Amyloid Precursor Protein Biosynthetic Process ATPase Binding Endopeptidase Activity Myelination Axon Ensheathment Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Peptidase Activity Cajal-Retzius Cell Differentiation Neuron Apoptotic Process Sarcolemma Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Short-term Synaptic Potentiation Negative Regulation Of Transcription By RNA Polymerase III Positive Regulation Of L-glutamate Import Across Plasma Membrane Synaptic Vesicle Targeting Astrocyte Activation Involved In Immune Response Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Sequestering Of Calcium Ion Positive Regulation Of Amyloid Fibril Formation Kinetochore Golgi Membrane Regulation Of Calcium Import Into The Mitochondrion Cytoplasmic Vesicle Membrane Glucose Import In Response To Insulin Stimulus Epithelial Cell Proliferation Schwann Cell Differentiation Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Regulation Of L-glutamate Import Across Plasma Membrane
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