ITM2C and STT3A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ITM2C	STT3A
Gene Name		integral membrane protein 2C	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane
	Molecular Function	Beta-amyloid Binding Protein Binding ATP Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Negative Regulation Of Neuron Projection Development Neuron Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein N-linked Glycosylation Via Asparagine Co-translational Protein Modification Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Schizophrenia ( 21926974)
Protein-Protein Interactions		5 interactors: BACE1 FURIN MTNR1B RNF7 STT3A	6 interactors: CSDE1 HJURP IRAK2 ITM2C SARM1 TMEM173
Entrez ID		81618	3703
HPRD ID		17167	03086
Ensembl ID		ENSG00000135916	ENSG00000134910
Uniprot IDs		Q9NQX7	B4DJ24 E9PNQ1 P46977
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Peptide Metabolic Process Co-translational Protein Modification Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Post-translational Protein Modification Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Amide Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Protein Neddylation Viral Protein Processing Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Response To Redox State Membrane Protein Ectodomain Proteolysis Signal Peptide Processing Beta-amyloid Metabolic Process Virion Assembly Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Peptide Biosynthetic Process Membrane Protein Proteolysis Peptide Hormone Processing	Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Innate Immune Response Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Immune Response Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Binding Cellular Response To Exogenous DsRNA Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Regulation Of Neuron Projection Development Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Interleukin-1-mediated Signaling Pathway Regulation Of Protein Import Into Nucleus, Translocation Response To Interferon-beta Immune Response-regulating Signaling Pathway Regulation Of Cell Projection Organization Nucleotide-binding Oligomerization Domain Containing Signaling Pathway CENP-A Containing Nucleosome Assembly Regulation Of Neuron Differentiation Regulation Of Defense Response To Virus By Host
Tagcloud ?			acceptor accessory allowed asparagine biosynthetic catalytic cotranslational cysteine duplication evolve folding glycosylated glycosylation magt1 maximize mediating metazoan oligosaccharides oligosaccharyltransferase organisms ost oxidoreductase posttranslocational progress sequentially skipped stt3b summarize traffic
Tagcloud (Difference) ?			acceptor accessory allowed asparagine biosynthetic catalytic cotranslational cysteine duplication evolve folding glycosylated glycosylation magt1 maximize mediating metazoan oligosaccharides oligosaccharyltransferase organisms ost oxidoreductase posttranslocational progress sequentially skipped stt3b summarize traffic
Tagcloud (Intersection) ?