CFHR5 and PANX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CFHR5	PANX1
Description		complement factor H related 5	pannexin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Protein-containing Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Bleb Protein-containing Complex
	Molecular Function	Complement Component C3b Binding Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Protease Binding Actin Binding Signaling Receptor Binding Structural Molecule Activity Gap Junction Channel Activity Monoatomic Anion Channel Activity Calcium Channel Activity ATP Transmembrane Transporter Activity Protein Binding Channel Activity Wide Pore Channel Activity Leak Channel Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process	Complement Activation Complement Activation, Alternative Pathway Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells	Response To Ischemia Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell-cell Signaling ATP Transport Cell Differentiation Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Response To ATP Monoatomic Ion Transmembrane Transport Oogenesis Positive Regulation Of Macrophage Cytokine Production Calcium Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport
Pathways		Regulation of Complement cascade	Electric Transmission Across Gap Junctions The NLRP3 inflammasome High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs			Probenecid
Diseases
GWAS		Age-related macular degeneration ( 23536807 23577725) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (MTAG) ( 32277175) Asthma ( 29273806) Lupus nephritis in systemic lupus erythematosus ( 24925725) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)	Alanine aminotransferase levels ( 33339817 33547301 34315874) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33339817 33547301 34315874) Autoimmune thyroid disease ( 32581359) Liver enzyme levels (alanine transaminase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		21 interacting genes: ARL13B C3 CFTR CISD2 CREB3 CREB3L1 EBAG9 ERGIC3 FFAR2 GPX8 KCNK7 LMNA PANX1 SLC10A1 SLC18A2 SLC4A1 SLC71A2 STOM TMEM14B TMEM237 TMPRSS2	16 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2
Entrez ID		81494	24145
HPRD ID		06508	10526
Ensembl ID		ENSG00000134389	ENSG00000110218
Uniprot IDs		Q9BXR6	Q96RD7
PDB IDs			6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN 7DWB 7F8J 7F8N 7F8O 7WSV 8GTS 8GTT 8GYO
Enriched GO Terms of Interacting Partners?		Membrane Bicarbonate Transmembrane Transporter Activity	Sterol Metabolic Process Channel Activity High-density Lipoprotein Particle Binding Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Lipid Catabolic Process Renal Water Homeostasis Disordered Domain Specific Binding Extrinsic Apoptotic Signaling Pathway Multicellular Organismal-level Water Homeostasis Lipoprotein Metabolic Process Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Cytokine Production Involved In Immune Response Sterol Biosynthetic Process Squalene Synthase [NAD(P)H] Activity Response To Fluid Shear Stress Response To Bacterium Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Positive Regulation Of Phagocytosis Peptidyl-methionine Modification Regulation Of Lipid Catabolic Process Cellular Response To Amyloid-beta Alcohol Metabolic Process Extracellular Region High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Catabolic Process Response To Amyloid-beta Lipid Biosynthetic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cholesterol Import Lumenal Side Of Membrane Response To Stress Cellular Response To Mercury Ion Cellular Response To Water Deprivation Multicellular Organismal-level Chemical Homeostasis Glycerol Transmembrane Transporter Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mu-type Opioid Receptor Binding Regulation Of Protein Secretion Positive Regulation Of Bleb Assembly Positive Regulation Of Interleukin-1 Production Regulation Of Amine Transport
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