P4HA1

Description		prolyl 4-hydroxylase subunit alpha 1
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Procollagen-proline 4-dioxygenase Complex
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Identical Protein Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Collagen Fibril Organization
Pathways		Collagen biosynthesis and modifying enzymes
Drugs		Ascorbic acid Proline Hydralazine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)
Novel Interacting Genes		1 novel interacting genes: CD48
Interacting Genes		3 interacting genes: MLF2 OGT SUMO2
Entrez ID		5033
HPRD ID		08901
Ensembl ID		ENSG00000122884
Uniprot IDs		P13674 Q5VSQ6
PDB IDs		1TJC 2V5F 2YQ8 4BT8 4BT9 4BTA 4BTB
Enriched GO Terms of Interacting Partners?		Glutamatergic Synapse Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Carbon Catabolite Regulation Of Transcription Regulation Of Transcription By Glucose NSL Complex Regulation Of Proteolysis Regulation Of Protein Catabolic Process
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