P4HA1 and MLF2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		P4HA1	MLF2
Description		prolyl 4-hydroxylase subunit alpha 1	myeloid leukemia factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Procollagen-proline 4-dioxygenase Complex	Nucleus Cytoplasm Membrane Synapse Glutamatergic Synapse
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Identical Protein Binding Metal Ion Binding Dioxygenase Activity	Protein Binding
	Biological Process	Collagen Fibril Organization	Regulation Of DNA-templated Transcription
Pathways		Collagen biosynthesis and modifying enzymes
Drugs		Ascorbic acid Proline Hydralazine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)	Bitter alcoholic beverage consumption ( 31046077) HDL cholesterol levels ( 32203549)
Interacting Genes		3 interacting genes: MLF2 OGT SUMO2	6 interacting genes: AKT1 HSPB2 P4HA1 SCGN TP53 USP7
Entrez ID		5033	8079
HPRD ID		08901	03238
Ensembl ID		ENSG00000122884	ENSG00000089693
Uniprot IDs		P13674 Q5VSQ6	A8K1F4 Q15773 Q5U0N1
PDB IDs		1TJC 2V5F 2YQ8 4BT8 4BT9 4BTA 4BTB
Enriched GO Terms of Interacting Partners?		Glutamatergic Synapse Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Carbon Catabolite Regulation Of Transcription Regulation Of Transcription By Glucose NSL Complex Regulation Of Proteolysis Regulation Of Protein Catabolic Process	Regulation Of Glucose Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of Small Molecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Telomere Maintenance PML Body Regulation Of DNA Metabolic Process Negative Regulation Of Proteolysis T Cell Apoptotic Process Replication Fork 14-3-3 Protein Binding Lymphocyte Apoptotic Process ER-nucleus Signaling Pathway Negative Regulation Of Macroautophagy Regulation Of Chromosome Organization Cellular Response To Nutrient Levels Regulation Of Release Of Cytochrome C From Mitochondria Leukocyte Apoptotic Process Negative Regulation Of Apoptotic Process Nucleotide-excision Repair Regulation Of Small Molecule Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of TORC1 Signaling Regulation Of Proteolysis Apoptotic Mitochondrial Changes Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of TRNA Methylation TORC1 Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Damage Checkpoint Signaling Mitochondrial Double-strand Break Repair Via Homologous Recombination P53 Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition TOR Signaling Response To Heat Regulation Of Cell Cycle Phase Transition Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Organelle Organization Site Of Double-strand Break DNA Damage Checkpoint Signaling Positive Regulation Of Protein Localization To Endoplasmic Reticulum Import Into Nucleus Response To Nutrient Levels Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Positive Regulation Of Organelle Organization
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