TSEN2 and TSEN54

Number of citations of the paper that reports this interaction (PMID 15109492)
44

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TSEN2	TSEN54
Gene Name		TSEN2 tRNA splicing endonuclease subunit	TSEN54 tRNA splicing endonuclease subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus Cytoplasm Centrosome	Nucleolus
	Molecular Function	TRNA-intron Endonuclease Activity Nucleic Acid Binding Lyase Activity
	Biological Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing
Pathways
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		2 interactors: RANBP10 TSEN54	3 interactors: BRCA1 CSNK2B TSEN2
Entrez ID		80746	283989
HPRD ID		10576	12291
Ensembl ID		ENSG00000154743	ENSG00000182173
Uniprot IDs		Q8NCE0	Q7Z6J9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ran GTPase Activity TRNA Splicing, Via Endonucleolytic Cleavage And Ligation	Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation TRNA-type Intron Splice Site Recognition And Cleavage Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Activin Receptor Signaling Pathway Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Adiponectin-activated Signaling Pathway Regulation Of Histone H3-K9 Acetylation Endothelial Tube Morphogenesis Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Cellular Response To Cytokine Stimulus Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Response To Cytokine Postreplication Repair Positive Regulation Of Protein Acetylation Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Genetic Imprinting Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Protein Modification Process G2 DNA Damage Checkpoint Positive Regulation Of Histone Methylation Negative Regulation Of Endothelial Cell Migration
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