TSEN2 and NUP210

		TSEN2	NUP210
Description		tRNA splicing endonuclease subunit 2	nucleoporin 210
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GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol	Nucleus Nuclear Envelope Nuclear Pore Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	TRNA-intron Lyase Activity Nucleic Acid Binding Protein Binding Lyase Activity	Protein Binding
	Biological Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing TRNA Processing	Nucleocytoplasmic Transport Protein Transport MRNA Transport
Pathways		tRNA processing in the nucleus	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases		Pontocerebellar hypoplasia
GWAS		A body shape index ( 34021172) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Systemic lupus erythematosus ( 28714469) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Coronary artery disease in type 1 diabetes ( 29695241)
Interacting Genes		7 interacting genes: CADPS CTAG2 GABPB2 RANBP10 TAX1BP1 TEPSIN TSEN54	4 interacting genes: CDK1 EXOSC5 MTDH TRIP6
Entrez ID		80746	23225
HPRD ID		10576	06368
Ensembl ID		ENSG00000154743	ENSG00000132182
Uniprot IDs		A0A7P0T8F8 A0A7P0T914 A0A7P0TA86 C9J7Z4 Q8NCE0	Q8TEM1
PDB IDs		7UXA 7ZRZ 8HMY 8HMZ 8ISS	7R5J 7R5K
Enriched GO Terms of Interacting Partners?
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